Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease.

Acetaldehyde-derived advanced glycation end-products promote alcoholic liver disease.

Chronic ingestion of ethanol increases acetaldehyde and leads to the production of acetaldehyde-derived advanced glycation end-products (AA-AGE). We evaluated the toxicity of AA-AGE on hepatocytes and studied the role of AA-AGE in the pathogenesis of alcoholic liver disease (ALD).Rat hepatocyte cult...

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Bibliographic Details
Main Authors:	Nobuhiko Hayashi, Joseph George, Masayoshi Takeuchi, Atsushi Fukumura, Nobuyuki Toshikuni, Tomiyasu Arisawa, Mikihiro Tsutsumi
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC3724722?pdf=render

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