Urine selenium concentration is a useful biomarker for assessing population level selenium status
Plasma selenium (Se) concentration is an established population level biomarker of Se status, especially in Se-deficient populations. Previously observed correlations between dietary Se intake and urinary Se excretion suggest that urine Se concentration is also a potentially viable biomarker of Se s...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412019323268 |
| _version_ | 1818448592492298240 |
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| author | Felix P. Phiri E. Louise Ander R. Murray Lark Elizabeth H. Bailey Benson Chilima Jellita Gondwe Edward J.M. Joy Alexander A. Kalimbira John C. Phuka Parminder S. Suchdev Daniel R.S. Middleton Elliott M. Hamilton Michael J. Watts Scott D. Young Martin R. Broadley |
| author_facet | Felix P. Phiri E. Louise Ander R. Murray Lark Elizabeth H. Bailey Benson Chilima Jellita Gondwe Edward J.M. Joy Alexander A. Kalimbira John C. Phuka Parminder S. Suchdev Daniel R.S. Middleton Elliott M. Hamilton Michael J. Watts Scott D. Young Martin R. Broadley |
| author_sort | Felix P. Phiri |
| collection | DOAJ |
| description | Plasma selenium (Se) concentration is an established population level biomarker of Se status, especially in Se-deficient populations. Previously observed correlations between dietary Se intake and urinary Se excretion suggest that urine Se concentration is also a potentially viable biomarker of Se status. However, there are only limited data on urine Se concentration among Se-deficient populations. Here, we test if urine is a viable biomarker for assessing Se status among a large sample of women and children in Malawi, most of whom are likely to be Se-deficient based on plasma Se status. Casual (spot) urine samples (n = 1406) were collected from a nationally representative sample of women of reproductive age (WRA, n =741) and school aged children (SAC, n=665) across Malawi as part of the 2015/16 Demographic and Health Survey. Selenium concentration in urine was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary dilution corrections for specific gravity, osmolality, and creatinine were applied to adjust for hydration status. Plasma Se status had been measured for the same survey participants. There was between-cluster variation in urine Se concentration that corresponded with variation in plasma Se concentration, but not between households within a cluster, or between individuals within a household. Corrected urine Se concentrations explained more of the between-cluster variation in plasma Se concentration than uncorrected data. These results provide new evidence that urine may be used in the surveillance of Se status at the population level in some groups. This could be a cost-effective option if urine samples are already being collected for other assessments, such as for iodine status analysis as in the Malawi and other national Demographic and Health Surveys. Keywords: Biomarkers, Biomonitoring, Micronutrient survey, Selenium status, Sub Saharan Africa, Urine |
| first_indexed | 2024-12-14T20:21:58Z |
| format | Article |
| id | doaj.art-ba642fbb32994ad99ebb36294af08015 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-14T20:21:58Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-ba642fbb32994ad99ebb36294af080152022-12-21T22:48:42ZengElsevierEnvironment International0160-41202020-01-01134Urine selenium concentration is a useful biomarker for assessing population level selenium statusFelix P. Phiri0E. Louise Ander1R. Murray Lark2Elizabeth H. Bailey3Benson Chilima4Jellita Gondwe5Edward J.M. Joy6Alexander A. Kalimbira7John C. Phuka8Parminder S. Suchdev9Daniel R.S. Middleton10Elliott M. Hamilton11Michael J. Watts12Scott D. Young13Martin R. Broadley14School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK; Department of Nutrition, HIV and AIDS, Ministry of Health, Lilongwe, Malawi; Corresponding author at: School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UK.Inorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, NG12 5GG, UKSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UKSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UKCommunity Health Sciences Unit, Ministry of Health, Private Bag 65, Lilongwe, MalawiCommunity Health Sciences Unit, Ministry of Health, Private Bag 65, Lilongwe, MalawiFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UKDepartment of Human Nutrition and Health, Faculty of Food and Human Sciences, Bunda Campus, Lilongwe University of Agriculture and Natural Resources, P.O. Box 219, Lilongwe, MalawiSchool of Public Health and Family Medicine, College of Medicine, University of Malawi, Private Bag 360, Chichiri, Blantyre 3, MalawiDepartment of Pediatrics and Hubert Department of Global Health, Emory University, Atlanta, GA 30322, USASection of Environment and Radiation, International Agency for Research on Cancer, World Health Organization, Lyon, FranceInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, NG12 5GG, UKInorganic Geochemistry, Centre for Environmental Geochemistry, British Geological Survey, NG12 5GG, UKSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UKSchool of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE12 5RD, UKPlasma selenium (Se) concentration is an established population level biomarker of Se status, especially in Se-deficient populations. Previously observed correlations between dietary Se intake and urinary Se excretion suggest that urine Se concentration is also a potentially viable biomarker of Se status. However, there are only limited data on urine Se concentration among Se-deficient populations. Here, we test if urine is a viable biomarker for assessing Se status among a large sample of women and children in Malawi, most of whom are likely to be Se-deficient based on plasma Se status. Casual (spot) urine samples (n = 1406) were collected from a nationally representative sample of women of reproductive age (WRA, n =741) and school aged children (SAC, n=665) across Malawi as part of the 2015/16 Demographic and Health Survey. Selenium concentration in urine was determined using inductively coupled plasma mass spectrometry (ICP-MS). Urinary dilution corrections for specific gravity, osmolality, and creatinine were applied to adjust for hydration status. Plasma Se status had been measured for the same survey participants. There was between-cluster variation in urine Se concentration that corresponded with variation in plasma Se concentration, but not between households within a cluster, or between individuals within a household. Corrected urine Se concentrations explained more of the between-cluster variation in plasma Se concentration than uncorrected data. These results provide new evidence that urine may be used in the surveillance of Se status at the population level in some groups. This could be a cost-effective option if urine samples are already being collected for other assessments, such as for iodine status analysis as in the Malawi and other national Demographic and Health Surveys. Keywords: Biomarkers, Biomonitoring, Micronutrient survey, Selenium status, Sub Saharan Africa, Urinehttp://www.sciencedirect.com/science/article/pii/S0160412019323268 |
| spellingShingle | Felix P. Phiri E. Louise Ander R. Murray Lark Elizabeth H. Bailey Benson Chilima Jellita Gondwe Edward J.M. Joy Alexander A. Kalimbira John C. Phuka Parminder S. Suchdev Daniel R.S. Middleton Elliott M. Hamilton Michael J. Watts Scott D. Young Martin R. Broadley Urine selenium concentration is a useful biomarker for assessing population level selenium status Environment International |
| title | Urine selenium concentration is a useful biomarker for assessing population level selenium status |
| title_full | Urine selenium concentration is a useful biomarker for assessing population level selenium status |
| title_fullStr | Urine selenium concentration is a useful biomarker for assessing population level selenium status |
| title_full_unstemmed | Urine selenium concentration is a useful biomarker for assessing population level selenium status |
| title_short | Urine selenium concentration is a useful biomarker for assessing population level selenium status |
| title_sort | urine selenium concentration is a useful biomarker for assessing population level selenium status |
| url | http://www.sciencedirect.com/science/article/pii/S0160412019323268 |
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