Autophagy orchestrates resistance in hepatocellular carcinoma cells
Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) in HCC cells. In addition, many experiments report a remarkable crosst...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002755 |
| _version_ | 1797857706994827264 |
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| author | Homeyra Seydi Kosar Nouri Niloufar Rezaei Atena Tamimi Moustapha Hassan Hamed Mirzaei Massoud Vosough |
| author_facet | Homeyra Seydi Kosar Nouri Niloufar Rezaei Atena Tamimi Moustapha Hassan Hamed Mirzaei Massoud Vosough |
| author_sort | Homeyra Seydi |
| collection | DOAJ |
| description | Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) in HCC cells. In addition, many experiments report a remarkable crosstalk between treatment resistance and autophagy pathways. Thus, autophagy could be one of the key factors enabling tumor cells to hinder induced cell death after medical interventions. Therefore, extensive research on the molecular pathways involved in resistance induction and autophagy have been conducted to achieve the desired therapeutic response. The key molecular pathways related to the therapy resistance are TGF-β, MAPK, NRF2, NF-κB, and non-coding RNAs. In addition, EMT, drug transports, apoptosis evasion, DNA repair, cancer stem cells, and hypoxia could have considerable impact on the hepatoma cell’s response to therapies. These mechanisms protect tumor cells against various treatments and many studies have shown that each of them is connected to the molecular pathways of autophagy induction in HCC. Hence, autophagy inhibition may be an effective strategy to improve therapeutic outcome in HCC patients. In this review, we further highlight how autophagy leads to poor response during treatment through a complex molecular network and how it enhances resistance in primary liver cancer. We propose that combinational regimens of approved HCC therapeutic protocols plus autophagy inhibitors may overcome drug resistance in HCC therapy. |
| first_indexed | 2024-04-09T21:02:11Z |
| format | Article |
| id | doaj.art-ba6466c4ded64f9cac1c002ed1c092bd |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:02:11Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-ba6466c4ded64f9cac1c002ed1c092bd2023-03-29T09:22:57ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114487Autophagy orchestrates resistance in hepatocellular carcinoma cellsHomeyra Seydi0Kosar Nouri1Niloufar Rezaei2Atena Tamimi3Moustapha Hassan4Hamed Mirzaei5Massoud Vosough6Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of Iran; Department of Biotechnology, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Islamic Republic of IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of IranExperimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, SwedenResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran; Corresponding author.Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of Iran; Experimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, Stockholm, Sweden; Corresponding author at: Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Islamic Republic of Iran.Treatment resistance is one of the major barriers for therapeutic strategies in hepatocellular carcinoma (HCC). Many studies have indicated that chemotherapy and radiotherapy induce autophagy machinery (cell protective autophagy) in HCC cells. In addition, many experiments report a remarkable crosstalk between treatment resistance and autophagy pathways. Thus, autophagy could be one of the key factors enabling tumor cells to hinder induced cell death after medical interventions. Therefore, extensive research on the molecular pathways involved in resistance induction and autophagy have been conducted to achieve the desired therapeutic response. The key molecular pathways related to the therapy resistance are TGF-β, MAPK, NRF2, NF-κB, and non-coding RNAs. In addition, EMT, drug transports, apoptosis evasion, DNA repair, cancer stem cells, and hypoxia could have considerable impact on the hepatoma cell’s response to therapies. These mechanisms protect tumor cells against various treatments and many studies have shown that each of them is connected to the molecular pathways of autophagy induction in HCC. Hence, autophagy inhibition may be an effective strategy to improve therapeutic outcome in HCC patients. In this review, we further highlight how autophagy leads to poor response during treatment through a complex molecular network and how it enhances resistance in primary liver cancer. We propose that combinational regimens of approved HCC therapeutic protocols plus autophagy inhibitors may overcome drug resistance in HCC therapy.http://www.sciencedirect.com/science/article/pii/S0753332223002755Hepatocellular carcinomaTreatment resistanceAutophagy pathwayResistance signaling pathwayAutophagy inducer pathway |
| spellingShingle | Homeyra Seydi Kosar Nouri Niloufar Rezaei Atena Tamimi Moustapha Hassan Hamed Mirzaei Massoud Vosough Autophagy orchestrates resistance in hepatocellular carcinoma cells Biomedicine & Pharmacotherapy Hepatocellular carcinoma Treatment resistance Autophagy pathway Resistance signaling pathway Autophagy inducer pathway |
| title | Autophagy orchestrates resistance in hepatocellular carcinoma cells |
| title_full | Autophagy orchestrates resistance in hepatocellular carcinoma cells |
| title_fullStr | Autophagy orchestrates resistance in hepatocellular carcinoma cells |
| title_full_unstemmed | Autophagy orchestrates resistance in hepatocellular carcinoma cells |
| title_short | Autophagy orchestrates resistance in hepatocellular carcinoma cells |
| title_sort | autophagy orchestrates resistance in hepatocellular carcinoma cells |
| topic | Hepatocellular carcinoma Treatment resistance Autophagy pathway Resistance signaling pathway Autophagy inducer pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002755 |
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