Synthesis and Biological Evaluation of Novel 4-(4-Formamidophenylamino)-<i>N</i>-methylpicolinamide Derivatives as Potential Antitumor Agents
A novel series of 4-(4-formamidophenylamino)-<i>N</i>-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT11...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/4/1150 |
| Summary: | A novel series of 4-(4-formamidophenylamino)-<i>N</i>-methylpicolinamide derivatives were synthesized and evaluated against different tumor cell lines. Experiments in vitro showed that these derivatives could inhibit the proliferation of two kinds of human cancer cell lines (HepG2, HCT116) at low micromolar concentrations and the most potent analog <b>5q</b> possessed broad-spectrum antiproliferative activity. Experiments in vivo demonstrated that <b>5q</b> could effectively prolong the longevity of colon carcinoma-burdened mice and slow down the progression of cancer cells by suppression of angiogenesis and the induction of apoptosis and necrosis. |
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| ISSN: | 1420-3049 |