Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease
AbstractIntroductions The effect of a low ankle-brachial index (ABI) in patients with advanced-stage diabetic kidney disease is not fully understood. This study investigates the prevalence of a low ABI in patients with advanced-stage diabetic kidney disease, which was defined as a urinary albumin-to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2160347 |
| _version_ | 1797658458218037248 |
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| author | Ruiying Tang Yun Liu Jiexin Chen Jihong Deng Yan Liu Qingdong Xu |
| author_facet | Ruiying Tang Yun Liu Jiexin Chen Jihong Deng Yan Liu Qingdong Xu |
| author_sort | Ruiying Tang |
| collection | DOAJ |
| description | AbstractIntroductions The effect of a low ankle-brachial index (ABI) in patients with advanced-stage diabetic kidney disease is not fully understood. This study investigates the prevalence of a low ABI in patients with advanced-stage diabetic kidney disease, which was defined as a urinary albumin-to-creatinine ratio (UACR) ≥300 mg/g and an estimated glomerular filtration rate (eGFR) between 15–60 mL/min/1.73 m2. Furthermore, the association between a low ABI and end-stage kidney disease (ESKD) was determined.Methods This single-center, retrospective, cohort study included 529 patients with advanced-stage diabetic kidney disease who were stratified into groups according to the ABI: high (>1.3), normal (0.9–1.3), and low (<0.9). The Kaplan-Meier method and Cox proportional analysis were used to examine the association between the ABI and ESKD.Results A total of 42.5% of patients with a low ABI progressed to ESKD. A low ABI was associated with a greater risk of ESKD (hazard ratio (HR): 1.073). After adjusting for traditional chronic kidney disease risk factors, a low ABI remained associated with a greater risk of ESKD (HR: 1.758; 95% confidence interval: 1.243–2.487; p = 0.001).Conclusions These results indicate that patients with a low ABI should be monitored carefully. Furthermore, preventive therapy should be considered to improve the long-term kidney survival of patients with residual kidney function. |
| first_indexed | 2024-03-11T18:00:22Z |
| format | Article |
| id | doaj.art-ba65508499214753b90264870e7d8d73 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-03-11T18:00:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-ba65508499214753b90264870e7d8d732023-10-17T09:23:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2022.2160347Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney diseaseRuiying Tang0Yun Liu1Jiexin Chen2Jihong Deng3Yan Liu4Qingdong Xu5Department of Nephrology, Jiangmen Central Hospital, Jiangmen City, ChinaDepartment of Nephrology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou City, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen City, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen City, ChinaDepartment of Nephrology, Guangzhou Red Cross Hospital, Jinan University, Guangzhou City, ChinaDepartment of Nephrology, Jiangmen Central Hospital, Jiangmen City, ChinaAbstractIntroductions The effect of a low ankle-brachial index (ABI) in patients with advanced-stage diabetic kidney disease is not fully understood. This study investigates the prevalence of a low ABI in patients with advanced-stage diabetic kidney disease, which was defined as a urinary albumin-to-creatinine ratio (UACR) ≥300 mg/g and an estimated glomerular filtration rate (eGFR) between 15–60 mL/min/1.73 m2. Furthermore, the association between a low ABI and end-stage kidney disease (ESKD) was determined.Methods This single-center, retrospective, cohort study included 529 patients with advanced-stage diabetic kidney disease who were stratified into groups according to the ABI: high (>1.3), normal (0.9–1.3), and low (<0.9). The Kaplan-Meier method and Cox proportional analysis were used to examine the association between the ABI and ESKD.Results A total of 42.5% of patients with a low ABI progressed to ESKD. A low ABI was associated with a greater risk of ESKD (hazard ratio (HR): 1.073). After adjusting for traditional chronic kidney disease risk factors, a low ABI remained associated with a greater risk of ESKD (HR: 1.758; 95% confidence interval: 1.243–2.487; p = 0.001).Conclusions These results indicate that patients with a low ABI should be monitored carefully. Furthermore, preventive therapy should be considered to improve the long-term kidney survival of patients with residual kidney function.https://www.tandfonline.com/doi/10.1080/0886022X.2022.2160347Ankle-brachial indexend-stage kidney diseasediabetesdiabetic kidney disease |
| spellingShingle | Ruiying Tang Yun Liu Jiexin Chen Jihong Deng Yan Liu Qingdong Xu Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease Renal Failure Ankle-brachial index end-stage kidney disease diabetes diabetic kidney disease |
| title | Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease |
| title_full | Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease |
| title_fullStr | Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease |
| title_full_unstemmed | Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease |
| title_short | Association of a low ankle brachial index with progression to end-stage kidney disease in patients with advanced-stage diabetic kidney disease |
| title_sort | association of a low ankle brachial index with progression to end stage kidney disease in patients with advanced stage diabetic kidney disease |
| topic | Ankle-brachial index end-stage kidney disease diabetes diabetic kidney disease |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2160347 |
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