Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.

Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension.

The endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) is an independent predictor of cardiovascular and overall mortality. Moreover, elevated ADMA plasma concentrations are associated with the extent of hypertension. However, data from small-sized clinical trials and expe...

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Main Authors: Karsten Sydow, Christine Schmitz, Eike-Christin von Leitner, Robin von Leitner, Anna Klinke, Dorothee Atzler, Christian Krebs, Hartwig Wieboldt, Heimo Ehmke, Edzard Schwedhelm, Thomas Meinertz, Stefan Blankenberg, Rainer H Böger, Tim Magnus, Stephan Baldus, Ulrich Wenzel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3482201?pdf=render

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