Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study
Structure and function in the human healthy brain are closely related. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent pa-tients results in hypoperf...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-10-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00135/full |
| _version_ | 1818278088908210176 |
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| author | Niklaus eDenier André eSchmidt Hana eGerber Otto eSchmid Anita eRiecher-Rössler Gerhard eWiesbeck Christian G. Huber Undine E. Lang Ernst-Wilhelm eRadue Marc eWalter Stefan eBorgwardt Stefan eBorgwardt |
| author_facet | Niklaus eDenier André eSchmidt Hana eGerber Otto eSchmid Anita eRiecher-Rössler Gerhard eWiesbeck Christian G. Huber Undine E. Lang Ernst-Wilhelm eRadue Marc eWalter Stefan eBorgwardt Stefan eBorgwardt |
| author_sort | Niklaus eDenier |
| collection | DOAJ |
| description | Structure and function in the human healthy brain are closely related. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent pa-tients results in hypoperfusion of fronto-temporal areas compared with the placebo condition. However, the relationship between structural and cerebral blood flow (CBF) changes in heroin addiction has not yet been investigated. Moreover, it is not known whether there is any interaction between the chronic structural changes and the short and long term effects on per-fusion caused by heroin. Using a double-blind, within-subject design, heroin or placebo (saline) was administrated to 15 heroin-dependent patients from a stable heroin-assisted treat-ment program, in order to observe acute short-term effects. Arterial spin labeling (ASL) was used to calculate perfusion quantification maps in both treatment conditions, while Voxel Based Morphometry (VBM) was conducted to calculate regional GM density. VBM and ASL data were used to calculate homologous correlation fields by Biological Parametric Mapping (BPM). We correlated each perfusion condition (heroin and placebo) separately with a VBM sample that was identical for the two treatment conditions. It was assumed that heroin-associated perfusion is manifested in short term effects, while placebo-associated perfusion is more related to long term effects. Correlation analyses revealed a significant positive correlation in frontal and temporal areas between GM and both perfusion conditions (heroin and placebo). The heroin-associated perfusion was also negatively correlated with GM in the left thalamus and right cuneus. These findings indicate that, in heroin-dependent patients, low GM volume is positively associated with low perfusion within fronto-temporal regions. |
| first_indexed | 2024-12-12T23:11:53Z |
| format | Article |
| id | doaj.art-ba6714c6de0849139023cd51d55f1307 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-12T23:11:53Z |
| publishDate | 2013-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-ba6714c6de0849139023cd51d55f13072022-12-22T00:08:35ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402013-10-01410.3389/fpsyt.2013.0013565642Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging studyNiklaus eDenier0André eSchmidt1Hana eGerber2Otto eSchmid3Anita eRiecher-Rössler4Gerhard eWiesbeck5Christian G. Huber6Undine E. Lang7Ernst-Wilhelm eRadue8Marc eWalter9Stefan eBorgwardt10Stefan eBorgwardt11University of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselMedical Image Analysis Centre (MIAC)University of BaselUniversity of BaselMedical Image Analysis Centre (MIAC)Structure and function in the human healthy brain are closely related. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent pa-tients results in hypoperfusion of fronto-temporal areas compared with the placebo condition. However, the relationship between structural and cerebral blood flow (CBF) changes in heroin addiction has not yet been investigated. Moreover, it is not known whether there is any interaction between the chronic structural changes and the short and long term effects on per-fusion caused by heroin. Using a double-blind, within-subject design, heroin or placebo (saline) was administrated to 15 heroin-dependent patients from a stable heroin-assisted treat-ment program, in order to observe acute short-term effects. Arterial spin labeling (ASL) was used to calculate perfusion quantification maps in both treatment conditions, while Voxel Based Morphometry (VBM) was conducted to calculate regional GM density. VBM and ASL data were used to calculate homologous correlation fields by Biological Parametric Mapping (BPM). We correlated each perfusion condition (heroin and placebo) separately with a VBM sample that was identical for the two treatment conditions. It was assumed that heroin-associated perfusion is manifested in short term effects, while placebo-associated perfusion is more related to long term effects. Correlation analyses revealed a significant positive correlation in frontal and temporal areas between GM and both perfusion conditions (heroin and placebo). The heroin-associated perfusion was also negatively correlated with GM in the left thalamus and right cuneus. These findings indicate that, in heroin-dependent patients, low GM volume is positively associated with low perfusion within fronto-temporal regions.http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00135/fullHeroin DependenceNeuroimagingPerfusionfMRIVBMvoxel-based morphometry |
| spellingShingle | Niklaus eDenier André eSchmidt Hana eGerber Otto eSchmid Anita eRiecher-Rössler Gerhard eWiesbeck Christian G. Huber Undine E. Lang Ernst-Wilhelm eRadue Marc eWalter Stefan eBorgwardt Stefan eBorgwardt Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study Frontiers in Psychiatry Heroin Dependence Neuroimaging Perfusion fMRI VBM voxel-based morphometry |
| title | Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study |
| title_full | Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study |
| title_fullStr | Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study |
| title_full_unstemmed | Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study |
| title_short | Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study |
| title_sort | association of frontal gray matter volume and cerebral perfusion in heroin addiction a multimodal neuroimaging study |
| topic | Heroin Dependence Neuroimaging Perfusion fMRI VBM voxel-based morphometry |
| url | http://journal.frontiersin.org/Journal/10.3389/fpsyt.2013.00135/full |
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