Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis
<p>Abstract</p> <p>Background</p> <p>Catechol-O-methyltransferase (<it>COMT</it>) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (<it>BC</it>) ris...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-10-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://www.diagnosticpathology.org/content/7/1/136 |
| _version_ | 1828490717759012864 |
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| author | Qin Xue Peng Qiliu Qin Aiping Chen Zhiping Lin Liwen Deng Yan Xie Li Xu Juanjuan Li Haiwei Li Taijie Li Shan Zhao Jinmin |
| author_facet | Qin Xue Peng Qiliu Qin Aiping Chen Zhiping Lin Liwen Deng Yan Xie Li Xu Juanjuan Li Haiwei Li Taijie Li Shan Zhao Jinmin |
| author_sort | Qin Xue |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Catechol-O-methyltransferase (<it>COMT</it>) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (<it>BC</it>) risk. Many epidemiological studies have been conducted to explore the association between the <it>COMT</it> Val158Met polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large meta-analysis was performed in this study.</p> <p>Methods</p> <p>Systematic searches of the PubMed, Embase and Cochrane Library were performed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.</p> <p>Results</p> <p>A total of 56 studies including 34,358 breast cancer cases and 45,429 controls were included. Overall, no significant associations between the <it>COMT</it> Val158Met polymorphism and breast cancer risk were found for LL versus HH, HL versus HH, LL versus HL, recessive model LL versus HL+HH, and dominant model LL+HL versus HH. In subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models.</p> <p><b>Conclusion</b></p> <p>Our meta-analysis results suggest that the <it>COMT</it> Val158Met polymorphism may not contribute to breast cancer susceptibility.</p> <p>Virtual slides</p> <p>The virtual slides(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs4806123577708417</url></p> |
| first_indexed | 2024-12-11T10:48:46Z |
| format | Article |
| id | doaj.art-ba673cbbc1354e09b9600f31878cc878 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-11T10:48:46Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-ba673cbbc1354e09b9600f31878cc8782022-12-22T01:10:24ZengBMCDiagnostic Pathology1746-15962012-10-017113610.1186/1746-1596-7-136Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysisQin XuePeng QiliuQin AipingChen ZhipingLin LiwenDeng YanXie LiXu JuanjuanLi HaiweiLi TaijieLi ShanZhao Jinmin<p>Abstract</p> <p>Background</p> <p>Catechol-O-methyltransferase (<it>COMT</it>) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (<it>BC</it>) risk. Many epidemiological studies have been conducted to explore the association between the <it>COMT</it> Val158Met polymorphism and breast cancer risk. However, the results remain inconclusive. In order to derive a more precise estimation of this relationship, a large meta-analysis was performed in this study.</p> <p>Methods</p> <p>Systematic searches of the PubMed, Embase and Cochrane Library were performed. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association.</p> <p>Results</p> <p>A total of 56 studies including 34,358 breast cancer cases and 45,429 controls were included. Overall, no significant associations between the <it>COMT</it> Val158Met polymorphism and breast cancer risk were found for LL versus HH, HL versus HH, LL versus HL, recessive model LL versus HL+HH, and dominant model LL+HL versus HH. In subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models.</p> <p><b>Conclusion</b></p> <p>Our meta-analysis results suggest that the <it>COMT</it> Val158Met polymorphism may not contribute to breast cancer susceptibility.</p> <p>Virtual slides</p> <p>The virtual slides(s) for this article can be found here: <url>http://www.diagnosticpathology.diagnomx.eu/vs4806123577708417</url></p>http://www.diagnosticpathology.org/content/7/1/136COMTPolymorphismBreast cancerMeta-analysis |
| spellingShingle | Qin Xue Peng Qiliu Qin Aiping Chen Zhiping Lin Liwen Deng Yan Xie Li Xu Juanjuan Li Haiwei Li Taijie Li Shan Zhao Jinmin Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis Diagnostic Pathology COMT Polymorphism Breast cancer Meta-analysis |
| title | Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis |
| title_full | Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis |
| title_fullStr | Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis |
| title_full_unstemmed | Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis |
| title_short | Association of <it>COMT</it> Val158Met polymorphism and breast cancer risk: an updated meta-analysis |
| title_sort | association of it comt it val158met polymorphism and breast cancer risk an updated meta analysis |
| topic | COMT Polymorphism Breast cancer Meta-analysis |
| url | http://www.diagnosticpathology.org/content/7/1/136 |
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