Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements
The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2018-04-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/29793 |
| _version_ | 1828195916634390528 |
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| author | Ali Mashhoori Saeedeh Hashemnia Bruce L McNaughton David R Euston Aaron J Gruber |
| author_facet | Ali Mashhoori Saeedeh Hashemnia Bruce L McNaughton David R Euston Aaron J Gruber |
| author_sort | Ali Mashhoori |
| collection | DOAJ |
| description | The anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred at target feeders. During excursions, the decoded position became more similar to a remote target feeder than the rat’s physical position. Excursions recruited activation of neurons encoding choice and reward, and the likelihood of excursions at a feeder was inversely correlated with feeder preference. These data suggest that the excursion phenomenon was related to evaluating real or fictive choice outcomes, particularly after disfavoured reinforcements. We propose that the multiplexing of position with choice-related information forms a mental model isomorphic with the task space, which can be mentally navigated via excursions to recall multimodal information about the utility of remote locations. |
| first_indexed | 2024-04-12T09:51:20Z |
| format | Article |
| id | doaj.art-ba68373170dc41c89504bae9276c71cb |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:51:20Z |
| publishDate | 2018-04-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-ba68373170dc41c89504bae9276c71cb2022-12-22T03:37:49ZengeLife Sciences Publications LtdeLife2050-084X2018-04-01710.7554/eLife.29793Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcementsAli Mashhoori0Saeedeh Hashemnia1https://orcid.org/0000-0001-8158-3145Bruce L McNaughton2David R Euston3Aaron J Gruber4https://orcid.org/0000-0003-2700-5429Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, CanadaCanadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Alberta, CanadaThe anterior cingulate cortex (ACC) encodes information supporting mnemonic and cognitive processes. We show here that a rat’s position can be decoded with high spatiotemporal resolution from ACC activity. ACC neurons encoded the current state of the animal and task, except for brief excursions that sometimes occurred at target feeders. During excursions, the decoded position became more similar to a remote target feeder than the rat’s physical position. Excursions recruited activation of neurons encoding choice and reward, and the likelihood of excursions at a feeder was inversely correlated with feeder preference. These data suggest that the excursion phenomenon was related to evaluating real or fictive choice outcomes, particularly after disfavoured reinforcements. We propose that the multiplexing of position with choice-related information forms a mental model isomorphic with the task space, which can be mentally navigated via excursions to recall multimodal information about the utility of remote locations.https://elifesciences.org/articles/29793prospectioncognitive mapdecodingneural networkensemble activitychoice |
| spellingShingle | Ali Mashhoori Saeedeh Hashemnia Bruce L McNaughton David R Euston Aaron J Gruber Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements eLife prospection cognitive map decoding neural network ensemble activity choice |
| title | Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| title_full | Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| title_fullStr | Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| title_full_unstemmed | Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| title_short | Rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| title_sort | rat anterior cingulate cortex recalls features of remote reward locations after disfavoured reinforcements |
| topic | prospection cognitive map decoding neural network ensemble activity choice |
| url | https://elifesciences.org/articles/29793 |
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