The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan
Koplik spots are considered a disease-specific sign for measles, although comprehensive virological studies have not been conducted to date. In Japan, a national survey of 3023 measles and measles-suspected cases was conducted between 2009 and 2014 using polymerase chain reaction (PCR) or reverse tr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00269/full |
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| author | Hirokazu Kimura Hirokazu Kimura Hirokazu Kimura Komei Shirabe Makoto Takeda Miho Kobayashi Hiroyuki Tsukagoshi Kaori Okayama Akihide Ryo Koo Nagasawa Koo Nagasawa Nobuhiko Okabe Nobuhiko Okabe Hiroko Minagawa Kunihisa Kozawa |
| author_facet | Hirokazu Kimura Hirokazu Kimura Hirokazu Kimura Komei Shirabe Makoto Takeda Miho Kobayashi Hiroyuki Tsukagoshi Kaori Okayama Akihide Ryo Koo Nagasawa Koo Nagasawa Nobuhiko Okabe Nobuhiko Okabe Hiroko Minagawa Kunihisa Kozawa |
| author_sort | Hirokazu Kimura |
| collection | DOAJ |
| description | Koplik spots are considered a disease-specific sign for measles, although comprehensive virological studies have not been conducted to date. In Japan, a national survey of 3023 measles and measles-suspected cases was conducted between 2009 and 2014 using polymerase chain reaction (PCR) or reverse transcription PCR (RT-PCR) to detect various rash/fever-associated viruses. Koplik spots were observed in 717 of 3023 cases (23.7%). Among these, the measles virus was detected in 202 cases (28.2%), while the rubella virus was detected in 125 cases (17.4%). Other viruses were detected in 51 cases having the spots (7.1%). In some of the cases with spots, two or three viruses, such as the rubella virus, parvovirus, and human herpesvirus type 6 were also detected. The sensitivity and specificity of Koplik spots as a diagnostic marker for measles were 48 and 80%, respectively. The results suggested that Koplik spots might appear not only in measles but also in other viral infections, such as rubella, as a clinical sign. |
| first_indexed | 2024-12-12T14:52:13Z |
| format | Article |
| id | doaj.art-ba686427e4b04f77ad322b4972e0609b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T14:52:13Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-ba686427e4b04f77ad322b4972e0609b2022-12-22T00:20:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-02-011010.3389/fmicb.2019.00269434614The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in JapanHirokazu Kimura0Hirokazu Kimura1Hirokazu Kimura2Komei Shirabe3Makoto Takeda4Miho Kobayashi5Hiroyuki Tsukagoshi6Kaori Okayama7Akihide Ryo8Koo Nagasawa9Koo Nagasawa10Nobuhiko Okabe11Nobuhiko Okabe12Hiroko Minagawa13Kunihisa Kozawa14Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Musashimurayama, JapanGraduate School of Health Science, Gunma Paz University, Takasaki, JapanDepartment of Microbiology, Graduate School of Medicine, Yokohama City University, Yokohama, JapanYamaguchi Prefectural Institute of Public Health and Environment, Yamaguchi, JapanDepartment of Virology III, National Institute of Infectious Diseases, Musashimurayama, JapanGunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, JapanGunma Prefectural Institute of Public Health and Environmental Sciences, Maebashi, JapanGraduate School of Health Science, Gunma Paz University, Takasaki, JapanDepartment of Microbiology, Graduate School of Medicine, Yokohama City University, Yokohama, JapanInfectious Disease Surveillance Center, National Institute of Infectious Diseases, Musashimurayama, JapanEastern Chiba Medical Center, Togane, JapanDepartment of Microbiology, Graduate School of Medicine, Yokohama City University, Yokohama, JapanKawasaki City Institute for Public Health, Kawasaki, JapanAichi Prefectural Institute of Public Health, Nagoya, JapanDepartment of Microbiology, Graduate School of Medicine, Yokohama City University, Yokohama, JapanKoplik spots are considered a disease-specific sign for measles, although comprehensive virological studies have not been conducted to date. In Japan, a national survey of 3023 measles and measles-suspected cases was conducted between 2009 and 2014 using polymerase chain reaction (PCR) or reverse transcription PCR (RT-PCR) to detect various rash/fever-associated viruses. Koplik spots were observed in 717 of 3023 cases (23.7%). Among these, the measles virus was detected in 202 cases (28.2%), while the rubella virus was detected in 125 cases (17.4%). Other viruses were detected in 51 cases having the spots (7.1%). In some of the cases with spots, two or three viruses, such as the rubella virus, parvovirus, and human herpesvirus type 6 were also detected. The sensitivity and specificity of Koplik spots as a diagnostic marker for measles were 48 and 80%, respectively. The results suggested that Koplik spots might appear not only in measles but also in other viral infections, such as rubella, as a clinical sign.https://www.frontiersin.org/article/10.3389/fmicb.2019.00269/fullmeaslesKoplik spotsRT-PCRrash and feverviral infection |
| spellingShingle | Hirokazu Kimura Hirokazu Kimura Hirokazu Kimura Komei Shirabe Makoto Takeda Miho Kobayashi Hiroyuki Tsukagoshi Kaori Okayama Akihide Ryo Koo Nagasawa Koo Nagasawa Nobuhiko Okabe Nobuhiko Okabe Hiroko Minagawa Kunihisa Kozawa The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan Frontiers in Microbiology measles Koplik spots RT-PCR rash and fever viral infection |
| title | The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan |
| title_full | The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan |
| title_fullStr | The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan |
| title_full_unstemmed | The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan |
| title_short | The Association Between Documentation of Koplik Spots and Laboratory Diagnosis of Measles and Other Rash Diseases in a National Measles Surveillance Program in Japan |
| title_sort | association between documentation of koplik spots and laboratory diagnosis of measles and other rash diseases in a national measles surveillance program in japan |
| topic | measles Koplik spots RT-PCR rash and fever viral infection |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.00269/full |
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