Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation

CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation. In this study, we found that the core fucosylation of CD4+ T cells was significantly...

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Bibliographic Details
Main Authors: Wei Liang, Shanshan Mao, Shijie Sun, Ming Li, Zhi Li, Rui Yu, Tonghui Ma, Jianguo Gu, Jianing Zhang, Naoyuki Taniguchi, Wenzhe Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
core fucosylation
T cell receptor
T cell activation
systemic lupus erythematosus
T–B cell interaction
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00078/full

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