Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults
Background: The associations between oral human herpesvirus-6 (HHV-6) and HHV-7, periodontal conditions, and lifestyle-related diseases, such as hypertension, diabetes, and dyslipidemia, have not been fully investigated in older adults. Methods: Seventy-four older patients who visited Hiroshima Univ...
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| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/324 |
| _version_ | 1797619855014232064 |
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| author | Natsuki Hamada Hideo Shigeishi Iori Oka Mio Sasaki Honami Kitasaki Mariko Nakamura Kanako Yano Chia-Hsin Wu Yoshino Kaneyasu Tomoko Maehara Masaru Sugiyama Kouji Ohta |
| author_facet | Natsuki Hamada Hideo Shigeishi Iori Oka Mio Sasaki Honami Kitasaki Mariko Nakamura Kanako Yano Chia-Hsin Wu Yoshino Kaneyasu Tomoko Maehara Masaru Sugiyama Kouji Ohta |
| author_sort | Natsuki Hamada |
| collection | DOAJ |
| description | Background: The associations between oral human herpesvirus-6 (HHV-6) and HHV-7, periodontal conditions, and lifestyle-related diseases, such as hypertension, diabetes, and dyslipidemia, have not been fully investigated in older adults. Methods: Seventy-four older patients who visited Hiroshima University Hospital were enrolled. Tongue swab samples were employed, and a real-time polymerase chain reaction was performed to detect HHV-6 and HHV-7 DNA. Dental plaque accumulation, probing pocket depth, and bleeding on probing (BOP) (i.e., a sign of periodontal inflammation) were examined. The periodontal inflamed surface area (PISA) value (i.e., an indicator of the severity of periodontitis) was also examined. Results: Of the 74 participants, one participant (1.4%) was HHV-6 DNA-positive and 36 participants (48.6%) were HHV-7 DNA-positive. A significant association between HHV-7 DNA and probing depth was found (<i>p</i> = 0.04). The HHV-7 DNA-positive participants had a higher positive rate of a ≥6-mm periodontal pocket with BOP (25.0%) than the HHV-7 DNA-negative participants (7.9%). Additionally, the HHV-7 DNA-positive participants had a higher PISA value than the HHV-7 DNA-negative participants. However, there was no significant association between HHV-7 and the PISA value (<i>p</i> = 0.82). No significant association was found between HHV-7 and lifestyle-related diseases (<i>p</i> > 0.05). Conclusions: Oral HHV-7 infection is associated with a deep periodontal pocket. |
| first_indexed | 2024-03-11T08:33:54Z |
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| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:33:54Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-ba6a76c66dee4a5d8af5a4a96476fec32023-11-16T21:39:41ZengMDPI AGLife2075-17292023-01-0113232410.3390/life13020324Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older AdultsNatsuki Hamada0Hideo Shigeishi1Iori Oka2Mio Sasaki3Honami Kitasaki4Mariko Nakamura5Kanako Yano6Chia-Hsin Wu7Yoshino Kaneyasu8Tomoko Maehara9Masaru Sugiyama10Kouji Ohta11Department of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Public Oral Health, Program of Oral Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanBackground: The associations between oral human herpesvirus-6 (HHV-6) and HHV-7, periodontal conditions, and lifestyle-related diseases, such as hypertension, diabetes, and dyslipidemia, have not been fully investigated in older adults. Methods: Seventy-four older patients who visited Hiroshima University Hospital were enrolled. Tongue swab samples were employed, and a real-time polymerase chain reaction was performed to detect HHV-6 and HHV-7 DNA. Dental plaque accumulation, probing pocket depth, and bleeding on probing (BOP) (i.e., a sign of periodontal inflammation) were examined. The periodontal inflamed surface area (PISA) value (i.e., an indicator of the severity of periodontitis) was also examined. Results: Of the 74 participants, one participant (1.4%) was HHV-6 DNA-positive and 36 participants (48.6%) were HHV-7 DNA-positive. A significant association between HHV-7 DNA and probing depth was found (<i>p</i> = 0.04). The HHV-7 DNA-positive participants had a higher positive rate of a ≥6-mm periodontal pocket with BOP (25.0%) than the HHV-7 DNA-negative participants (7.9%). Additionally, the HHV-7 DNA-positive participants had a higher PISA value than the HHV-7 DNA-negative participants. However, there was no significant association between HHV-7 and the PISA value (<i>p</i> = 0.82). No significant association was found between HHV-7 and lifestyle-related diseases (<i>p</i> > 0.05). Conclusions: Oral HHV-7 infection is associated with a deep periodontal pocket.https://www.mdpi.com/2075-1729/13/2/324human herpesvirus-7real-time polymerase chain reactionperiodontitisolder adults |
| spellingShingle | Natsuki Hamada Hideo Shigeishi Iori Oka Mio Sasaki Honami Kitasaki Mariko Nakamura Kanako Yano Chia-Hsin Wu Yoshino Kaneyasu Tomoko Maehara Masaru Sugiyama Kouji Ohta Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults Life human herpesvirus-7 real-time polymerase chain reaction periodontitis older adults |
| title | Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults |
| title_full | Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults |
| title_fullStr | Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults |
| title_full_unstemmed | Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults |
| title_short | Associations between Oral Human Herpesvirus-6 and -7 and Periodontal Conditions in Older Adults |
| title_sort | associations between oral human herpesvirus 6 and 7 and periodontal conditions in older adults |
| topic | human herpesvirus-7 real-time polymerase chain reaction periodontitis older adults |
| url | https://www.mdpi.com/2075-1729/13/2/324 |
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