Extracellular Inflammasome Particles Are Released After Marathon Running and Induce Proinflammatory Effects in Endothelial Cells

Extracellular Inflammasome Particles Are Released After Marathon Running and Induce Proinflammatory Effects in Endothelial Cells

Objectives: The intracellular NLRP3 inflammasome is an important regulator of sterile inflammation. Recent data suggest that inflammasome particles can be released into circulation. The effects of exercise on circulating extracellular apoptosis-associated speck-like protein (ASC) particles and their...

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Main Authors: Alexander Kogel, Sven Fikenzer, Luisa Uhlmann, Lena Opitz, Jasmin M. Kneuer, Karl Georg Haeusler, Matthias Endres, Jürgen Kratzsch, Viktoria Schwarz, Christian Werner, Hermann Kalwa, Susanne Gaul, Ulrich Laufs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Physiology
Subjects:
marathon
NLRP3
inflammasome
cardiovascular disease
endothelial dysfunction
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.866938/full

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