Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma
Objective(s): Breast carcinoma is the most common type of cancer in females. This study aims to compare fluorine-18-fluorodeoxyglucose (18F-FDG) uptake pattern and apparent diffusion coefficient (ADC) value for the detection of the primary tumour and axillary metastases of invasive ductal breast car...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2024-01-01
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| Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
| Subjects: | |
| Online Access: | https://aojnmb.mums.ac.ir/article_22622_111aac7de1b3ed1740370d4015889e45.pdf |
| _version_ | 1797377711593750528 |
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| author | Aynur Ozen Tarık Sayın Ozan Kandemir Ozgul Ekmekcioğlu Serdar Altınay Eylem Bastug Ali Muhammedoğlu Atilla Celik Ramazan Albayrak |
| author_facet | Aynur Ozen Tarık Sayın Ozan Kandemir Ozgul Ekmekcioğlu Serdar Altınay Eylem Bastug Ali Muhammedoğlu Atilla Celik Ramazan Albayrak |
| author_sort | Aynur Ozen |
| collection | DOAJ |
| description | Objective(s): Breast carcinoma is the most common type of cancer in females. This study aims to compare fluorine-18-fluorodeoxyglucose (18F-FDG) uptake pattern and apparent diffusion coefficient (ADC) value for the detection of the primary tumour and axillary metastases of invasive ductal breast carcinoma.Methods: This study included 40 breast carcinoma lesions taken from 39 patients. After staging by positron emission tomography-computed tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (MRI), breast surgery with axillary lymph node dissection or sentinel lymph node biopsy was performed.Results: Primary lesion detection rate for PET/CT and diffusion-weighted MRI was high with 39 of 40 lesions (97.5%). The sensitivity and specificity for the detection of metastatic lymph nodes in axilla were 40.9%, 88.9%, with 18F-FDG PET/CT scans and 40.9%, 83.3%, for dw-MRI, respectively. No significant correlation was detected between ADC and SUVmax or SUVmax ratios. Estrogen receptor (p=0.007) and progesterone receptor (p=0.036) positive patients had lower ADC values. Tumour SUVmax was lower in T1 than T2 tumour size (p=0.027) and progesterone receptor-positive patients (p=0.029). Tumour/background SUVmax was lower in progesterone receptor-positive patients (p=0.004). Tumour/liver SUVmax was higher in grade III patients (p=0.035) and progesterone receptor negative status (p=0.043).Conclusions: This study confirmed the high detection rate of breast carcinoma in both modalities. They have same sensitivity for the detection of axillary lymph node metastases, whereas the PET/CT scan had higher specificity. Furthermore, ADC, SUVmax and SUVmax ratios showed some statistical significance among the patient groups according to different pathological parameters. |
| first_indexed | 2024-03-08T19:57:27Z |
| format | Article |
| id | doaj.art-ba6d877ed3e44d13b71bb9e106045895 |
| institution | Directory Open Access Journal |
| issn | 2322-5718 2322-5726 |
| language | English |
| last_indexed | 2024-03-08T19:57:27Z |
| publishDate | 2024-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Asia Oceania Journal of Nuclear Medicine and Biology |
| spelling | doaj.art-ba6d877ed3e44d13b71bb9e1060458952023-12-24T05:33:47ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262024-01-01121112010.22038/aojnmb.2023.70534.149322622Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinomaAynur Ozen0Tarık Sayın1Ozan Kandemir2Ozgul Ekmekcioğlu3Serdar Altınay4Eylem Bastug5Ali Muhammedoğlu6Atilla Celik7Ramazan Albayrak8Department of Nuclear Medicine, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of Radiology, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of Nuclear Medicine, Mugla Training and Research Hospital, Mugla Sıtkı Kocman University, Mugla, TurkeyDepartment of Nuclear Medicine, Istanbul Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey5Department of Pathology, Istanbul Bakırköy Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of Nuclear Medicine, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of Pathology, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of General Surgery, Istanbul Bagcılar Training and Research Hospital, University of Health Sciences, Istanbul, TurkeyDepartment of Radiology, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, TurkeyObjective(s): Breast carcinoma is the most common type of cancer in females. This study aims to compare fluorine-18-fluorodeoxyglucose (18F-FDG) uptake pattern and apparent diffusion coefficient (ADC) value for the detection of the primary tumour and axillary metastases of invasive ductal breast carcinoma.Methods: This study included 40 breast carcinoma lesions taken from 39 patients. After staging by positron emission tomography-computed tomography (PET/CT) and diffusion-weighted magnetic resonance imaging (MRI), breast surgery with axillary lymph node dissection or sentinel lymph node biopsy was performed.Results: Primary lesion detection rate for PET/CT and diffusion-weighted MRI was high with 39 of 40 lesions (97.5%). The sensitivity and specificity for the detection of metastatic lymph nodes in axilla were 40.9%, 88.9%, with 18F-FDG PET/CT scans and 40.9%, 83.3%, for dw-MRI, respectively. No significant correlation was detected between ADC and SUVmax or SUVmax ratios. Estrogen receptor (p=0.007) and progesterone receptor (p=0.036) positive patients had lower ADC values. Tumour SUVmax was lower in T1 than T2 tumour size (p=0.027) and progesterone receptor-positive patients (p=0.029). Tumour/background SUVmax was lower in progesterone receptor-positive patients (p=0.004). Tumour/liver SUVmax was higher in grade III patients (p=0.035) and progesterone receptor negative status (p=0.043).Conclusions: This study confirmed the high detection rate of breast carcinoma in both modalities. They have same sensitivity for the detection of axillary lymph node metastases, whereas the PET/CT scan had higher specificity. Furthermore, ADC, SUVmax and SUVmax ratios showed some statistical significance among the patient groups according to different pathological parameters.https://aojnmb.mums.ac.ir/article_22622_111aac7de1b3ed1740370d4015889e45.pdfbreast carcinomapositron emission tomographystandardized maximal uptakeapparent diffusion coefficientdiffusion magnetic resonance imaging |
| spellingShingle | Aynur Ozen Tarık Sayın Ozan Kandemir Ozgul Ekmekcioğlu Serdar Altınay Eylem Bastug Ali Muhammedoğlu Atilla Celik Ramazan Albayrak Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma Asia Oceania Journal of Nuclear Medicine and Biology breast carcinoma positron emission tomography standardized maximal uptake apparent diffusion coefficient diffusion magnetic resonance imaging |
| title | Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma |
| title_full | Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma |
| title_fullStr | Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma |
| title_full_unstemmed | Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma |
| title_short | Comparison between 18F-FDG PET/CT and diffusion-weighted imaging in detection of invasive ductal breast carcinoma |
| title_sort | comparison between 18f fdg pet ct and diffusion weighted imaging in detection of invasive ductal breast carcinoma |
| topic | breast carcinoma positron emission tomography standardized maximal uptake apparent diffusion coefficient diffusion magnetic resonance imaging |
| url | https://aojnmb.mums.ac.ir/article_22622_111aac7de1b3ed1740370d4015889e45.pdf |
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