OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions
Ion transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-07-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00855/full |
| _version_ | 1818539438868791296 |
|---|---|
| author | Eszter Becskeházi Marietta Margaréta Korsós Bálint Erőss Péter Hegyi Péter Hegyi Péter Hegyi Viktória Venglovecz |
| author_facet | Eszter Becskeházi Marietta Margaréta Korsós Bálint Erőss Péter Hegyi Péter Hegyi Péter Hegyi Viktória Venglovecz |
| author_sort | Eszter Becskeházi |
| collection | DOAJ |
| description | Ion transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change in the function or expression of ion transporters has significance in the development or neoplastic progression of Barrett’s oesophagus (BO). In this review, we discuss the physiological and pathophysiological roles of ion transporters in the oesophagus, highlighting transport proteins which serve as therapeutic targets or prognostic markers in eosinophilic oesophagitis, BO and esophageal cancer. We believe that this review highlights important relationships which might contribute to a better understanding of the pathomechanisms of esophageal diseases. |
| first_indexed | 2024-12-11T21:42:02Z |
| format | Article |
| id | doaj.art-ba6e11efe33e42089eb223748830768b |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T21:42:02Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-ba6e11efe33e42089eb223748830768b2022-12-22T00:49:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00855561046OEsophageal Ion Transport Mechanisms and Significance Under Pathological ConditionsEszter Becskeházi0Marietta Margaréta Korsós1Bálint Erőss2Péter Hegyi3Péter Hegyi4Péter Hegyi5Viktória Venglovecz6Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, HungaryDepartment of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, HungaryInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, Pécs, HungaryDivision of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, HungaryFirst Department of Medicine, University of Szeged, Szeged, HungaryDepartment of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, HungaryIon transporters play an important role in several physiological functions, such as cell volume regulation, pH homeostasis and secretion. In the oesophagus, ion transport proteins are part of the epithelial resistance, a mechanism which protects the oesophagus against reflux-induced damage. A change in the function or expression of ion transporters has significance in the development or neoplastic progression of Barrett’s oesophagus (BO). In this review, we discuss the physiological and pathophysiological roles of ion transporters in the oesophagus, highlighting transport proteins which serve as therapeutic targets or prognostic markers in eosinophilic oesophagitis, BO and esophageal cancer. We believe that this review highlights important relationships which might contribute to a better understanding of the pathomechanisms of esophageal diseases.https://www.frontiersin.org/article/10.3389/fphys.2020.00855/fullion transportoesophagusBarrett oesophaguseosinophilic oesophagusoesophageal cancer |
| spellingShingle | Eszter Becskeházi Marietta Margaréta Korsós Bálint Erőss Péter Hegyi Péter Hegyi Péter Hegyi Viktória Venglovecz OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions Frontiers in Physiology ion transport oesophagus Barrett oesophagus eosinophilic oesophagus oesophageal cancer |
| title | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
| title_full | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
| title_fullStr | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
| title_full_unstemmed | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
| title_short | OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions |
| title_sort | oesophageal ion transport mechanisms and significance under pathological conditions |
| topic | ion transport oesophagus Barrett oesophagus eosinophilic oesophagus oesophageal cancer |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00855/full |
| work_keys_str_mv | AT eszterbecskehazi oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT mariettamargaretakorsos oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT balinteross oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT peterhegyi oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT peterhegyi oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT peterhegyi oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions AT viktoriavenglovecz oesophagealiontransportmechanismsandsignificanceunderpathologicalconditions |