A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging
Objective To investigate the efficacy and safety of combined anticoagulants with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis (CVST) under the assistance of high resolution magnetic resonance black⁃blood thrombus imaging (MRBTI). Methods and Results A retrospectiv...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2022-06-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2515 |
| _version_ | 1811238019762487296 |
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| author | WANG Wei FAN Yi⁃mu JIA Qiang LI Xu⁃dong WANG Shi⁃bo TONG Xiao⁃guang |
| author_facet | WANG Wei FAN Yi⁃mu JIA Qiang LI Xu⁃dong WANG Shi⁃bo TONG Xiao⁃guang |
| author_sort | WANG Wei |
| collection | DOAJ |
| description | Objective To investigate the efficacy and safety of combined anticoagulants with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis (CVST) under the assistance of high resolution magnetic resonance black⁃blood thrombus imaging (MRBTI). Methods and Results A retrospective study was performed on the patients with CVST who were treated at Department of Neurosurgery of Tianjin Huanhu Hospital from January 2019 to January 2021. Preoperative high resolution MRBTI confirmed 15 patients with subacute and chronic CVST, and endovascular treatment was performed on the basis of systemic anticoagulant therapy. The results showed that 10 cases were in subacute stage and 5 cases were in chronic stage. After treatment, the venous sinus was completely recanalized in 4 cases and partially recanalized in 11 cases. Complications occurred in 2 cases (intracranial hematoma enlarged in one case, microguide wire penetrated straight sinus wall during surgery in one case), contact thrombolytic therapy was continued after the condition stabilized. The mean indwelling time of microcatheter in straight sinus was (6.27 ± 0.21) d and the mean length of hospital stay was (11.53 ± 1.30) d. The degree of impairment of consciousness [Glasgow Coma Scale (GCS) score] was improved at discharge [at discharge (13.67 ± 2.02) score vs. at admission (11.67 ± 2.13) score; t = 9.165, P = 0.000], the degree of neurological impairment [modified Rankin Scale (mRS) score] was improved 6 months after surgery [at 6 months after surgery 1 (0, 2) score vs. at admission 3 (2, 4) score; Z = ⁃ 3.624, P = 0.000]. Conclusions High resolution MRBTI is an effective technique to identify subacute and chronic CVST patients. For these patients, the combination of systemic anticoagulation and endovascular treatment can reduce venous sinus thrombosis load and improve symptoms in a short time, which is a safe, effective and preferred treatment. |
| first_indexed | 2024-04-12T12:34:34Z |
| format | Article |
| id | doaj.art-ba6ed2a6f30a44dd9f39e2b9e346a364 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-12T12:34:34Z |
| publishDate | 2022-06-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-ba6ed2a6f30a44dd9f39e2b9e346a3642022-12-22T03:32:57ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312022-06-0122646547110.3969/j.issn.1672⁃6731.2022.06.005A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imagingWANG Wei0FAN Yi⁃mu1JIA Qiang2LI Xu⁃dong3WANG Shi⁃bo4TONG Xiao⁃guang5Grade 2017, Graduate School, Tianjin Medical UniversityDepartment of Neurosurgery, Tianjin Huanhu HospitalDepartment of Neurosurgery, Tianjin Huanhu HospitalDepartment of Neurosurgery, Tianjin Huanhu HospitalDepartment of Neurosurgery, Tianjin Huanhu HospitalDepartment of Neurosurgery, Tianjin Huanhu HospitalObjective To investigate the efficacy and safety of combined anticoagulants with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis (CVST) under the assistance of high resolution magnetic resonance black⁃blood thrombus imaging (MRBTI). Methods and Results A retrospective study was performed on the patients with CVST who were treated at Department of Neurosurgery of Tianjin Huanhu Hospital from January 2019 to January 2021. Preoperative high resolution MRBTI confirmed 15 patients with subacute and chronic CVST, and endovascular treatment was performed on the basis of systemic anticoagulant therapy. The results showed that 10 cases were in subacute stage and 5 cases were in chronic stage. After treatment, the venous sinus was completely recanalized in 4 cases and partially recanalized in 11 cases. Complications occurred in 2 cases (intracranial hematoma enlarged in one case, microguide wire penetrated straight sinus wall during surgery in one case), contact thrombolytic therapy was continued after the condition stabilized. The mean indwelling time of microcatheter in straight sinus was (6.27 ± 0.21) d and the mean length of hospital stay was (11.53 ± 1.30) d. The degree of impairment of consciousness [Glasgow Coma Scale (GCS) score] was improved at discharge [at discharge (13.67 ± 2.02) score vs. at admission (11.67 ± 2.13) score; t = 9.165, P = 0.000], the degree of neurological impairment [modified Rankin Scale (mRS) score] was improved 6 months after surgery [at 6 months after surgery 1 (0, 2) score vs. at admission 3 (2, 4) score; Z = ⁃ 3.624, P = 0.000]. Conclusions High resolution MRBTI is an effective technique to identify subacute and chronic CVST patients. For these patients, the combination of systemic anticoagulation and endovascular treatment can reduce venous sinus thrombosis load and improve symptoms in a short time, which is a safe, effective and preferred treatment.http://www.cjcnn.org/index.php/cjcnn/article/view/2515sinus thrombosisintracranialcerebral veinsmagnetic resonance imaginganticoagulantsmechanical thrombolysis |
| spellingShingle | WANG Wei FAN Yi⁃mu JIA Qiang LI Xu⁃dong WANG Shi⁃bo TONG Xiao⁃guang A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging Chinese Journal of Contemporary Neurology and Neurosurgery sinus thrombosis intracranial cerebral veins magnetic resonance imaging anticoagulants mechanical thrombolysis |
| title | A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| title_full | A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| title_fullStr | A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| title_full_unstemmed | A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| title_short | A preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| title_sort | preliminary study on the efficacy of anticoagulants combined with endovascular treatment for subacute and chronic cerebral venous sinus thrombosis assisted by high resolution magnetic resonance black⁃blood thrombus imaging |
| topic | sinus thrombosis intracranial cerebral veins magnetic resonance imaging anticoagulants mechanical thrombolysis |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2515 |
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