Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of consuming n-3 polyunsaturated fatty acids (PUFAs) for...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4917109?pdf=render |
| _version_ | 1811321944216174592 |
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| author | Noriko Suzuki-Kemuriyama Takashi Matsuzaka Motoko Kuba Hiroshi Ohno Song-Iee Han Yoshinori Takeuchi Masaaki Isaka Kazuto Kobayashi Hitoshi Iwasaki Shigeru Yatoh Hiroaki Suzuki Katsuhiro Miyajima Dai Nakae Naoya Yahagi Yoshimi Nakagawa Hirohito Sone Nobuhiro Yamada Hitoshi Shimano |
| author_facet | Noriko Suzuki-Kemuriyama Takashi Matsuzaka Motoko Kuba Hiroshi Ohno Song-Iee Han Yoshinori Takeuchi Masaaki Isaka Kazuto Kobayashi Hitoshi Iwasaki Shigeru Yatoh Hiroaki Suzuki Katsuhiro Miyajima Dai Nakae Naoya Yahagi Yoshimi Nakagawa Hirohito Sone Nobuhiro Yamada Hitoshi Shimano |
| author_sort | Noriko Suzuki-Kemuriyama |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of consuming n-3 polyunsaturated fatty acids (PUFAs) for the treatment of NAFLD. In the present study, we investigated and compared the effects of the major n-3 PUFAs-eicosapentaenoic acid (EPA, C20:5) and docosahexaenoic acid (DHA, C22:6)-in preventing atherogenic high-fat (AHF) diet-induced NAFLD. Mice were fed the AHF diet supplemented with or without EPA or DHA for four weeks. Both EPA and DHA reduced the pathological features of AHF diet-induced NASH pathologies such as hepatic lobular inflammation and elevated serum transaminase activity. Intriguingly, EPA had a greater hepatic triacylglycerol (TG)-reducing effect than DHA. In contrast, DHA had a greater suppressive effect than EPA on AHF diet-induced hepatic inflammation and ROS generation, but no difference in fibrosis. Both EPA and DHA could be effective for treatment of NAFLD and NASH. Meanwhile, the two major n-3 polyunsaturated fatty acids might differ in a relative contribution to pathological intermediate steps towards liver fibrosis. |
| first_indexed | 2024-04-13T13:26:29Z |
| format | Article |
| id | doaj.art-ba72cf7df6544c9194ad881ba3772ffe |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:26:29Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ba72cf7df6544c9194ad881ba3772ffe2022-12-22T02:45:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01116e015758010.1371/journal.pone.0157580Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.Noriko Suzuki-KemuriyamaTakashi MatsuzakaMotoko KubaHiroshi OhnoSong-Iee HanYoshinori TakeuchiMasaaki IsakaKazuto KobayashiHitoshi IwasakiShigeru YatohHiroaki SuzukiKatsuhiro MiyajimaDai NakaeNaoya YahagiYoshimi NakagawaHirohito SoneNobuhiro YamadaHitoshi ShimanoNon-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of consuming n-3 polyunsaturated fatty acids (PUFAs) for the treatment of NAFLD. In the present study, we investigated and compared the effects of the major n-3 PUFAs-eicosapentaenoic acid (EPA, C20:5) and docosahexaenoic acid (DHA, C22:6)-in preventing atherogenic high-fat (AHF) diet-induced NAFLD. Mice were fed the AHF diet supplemented with or without EPA or DHA for four weeks. Both EPA and DHA reduced the pathological features of AHF diet-induced NASH pathologies such as hepatic lobular inflammation and elevated serum transaminase activity. Intriguingly, EPA had a greater hepatic triacylglycerol (TG)-reducing effect than DHA. In contrast, DHA had a greater suppressive effect than EPA on AHF diet-induced hepatic inflammation and ROS generation, but no difference in fibrosis. Both EPA and DHA could be effective for treatment of NAFLD and NASH. Meanwhile, the two major n-3 polyunsaturated fatty acids might differ in a relative contribution to pathological intermediate steps towards liver fibrosis.http://europepmc.org/articles/PMC4917109?pdf=render |
| spellingShingle | Noriko Suzuki-Kemuriyama Takashi Matsuzaka Motoko Kuba Hiroshi Ohno Song-Iee Han Yoshinori Takeuchi Masaaki Isaka Kazuto Kobayashi Hitoshi Iwasaki Shigeru Yatoh Hiroaki Suzuki Katsuhiro Miyajima Dai Nakae Naoya Yahagi Yoshimi Nakagawa Hirohito Sone Nobuhiro Yamada Hitoshi Shimano Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. PLoS ONE |
| title | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. |
| title_full | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. |
| title_fullStr | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. |
| title_full_unstemmed | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. |
| title_short | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. |
| title_sort | different effects of eicosapentaenoic and docosahexaenoic acids on atherogenic high fat diet induced non alcoholic fatty liver disease in mice |
| url | http://europepmc.org/articles/PMC4917109?pdf=render |
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