Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is one of the most common medical disorders in pregnancy. Adipokines, predominantly secreted by adipose tissue, are involved in numerous metabolic processes. The exact role of adipokines in the pathogenesis of GDM is still not well known, and numerous adipokines h...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/25/1/175 |
| _version_ | 1797358750628052992 |
|---|---|
| author | Maciej Kamiński Radzisław Mierzyński Elżbieta Poniedziałek-Czajkowska Agata Sadowska Maciej Sotowski Bożena Leszczyńska-Gorzelak |
| author_facet | Maciej Kamiński Radzisław Mierzyński Elżbieta Poniedziałek-Czajkowska Agata Sadowska Maciej Sotowski Bożena Leszczyńska-Gorzelak |
| author_sort | Maciej Kamiński |
| collection | DOAJ |
| description | Gestational diabetes mellitus (GDM) is one of the most common medical disorders in pregnancy. Adipokines, predominantly secreted by adipose tissue, are involved in numerous metabolic processes. The exact role of adipokines in the pathogenesis of GDM is still not well known, and numerous adipokines have been analysed throughout pregnancy and proposed as biomarkers of GDM. This study aimed to evaluate serum adiponectin, chemerin, lipocalin and apelin levels in GDM and non-GDM women, to assess them as clinically useful biomarkers of the occurrence of GDM and to demonstrate the correlation between the levels of the above adipokines in the blood serum and the increased risk of the development of GDM. The role of these adipokines in the pathogenesis of GDM was also analysed. The statistically significant differences between the levels of adiponectin (7234.6 vs. 9837.5 ng/mL, <i>p</i> < 0.0001), chemerin (264.0 vs. 206.7 ng/mL, <i>p</i> < 0.0001) and lipocalin (39.5 vs. 19.4 ng/mL, <i>p</i> < 0.0001) were observed between pregnant women with GDM and healthy ones. The diagnostic usefulness of the tested adipokines in detecting GDM was also assessed. The research results confirm the hypothesis on the significance of adiponectin, chemerin, lipocalin and apelin in the pathophysiological mechanisms of GDM. We speculate that these adipokines could potentially be established as novel biomarkers for the prediction and early diagnosis of GDM. |
| first_indexed | 2024-03-08T15:06:40Z |
| format | Article |
| id | doaj.art-ba73db22f3bd42da8e0d5df9c612eecc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:06:40Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ba73db22f3bd42da8e0d5df9c612eecc2024-01-10T14:58:26ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125117510.3390/ijms25010175Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes MellitusMaciej Kamiński0Radzisław Mierzyński1Elżbieta Poniedziałek-Czajkowska2Agata Sadowska3Maciej Sotowski4Bożena Leszczyńska-Gorzelak5Chair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-954 Lublin, PolandGestational diabetes mellitus (GDM) is one of the most common medical disorders in pregnancy. Adipokines, predominantly secreted by adipose tissue, are involved in numerous metabolic processes. The exact role of adipokines in the pathogenesis of GDM is still not well known, and numerous adipokines have been analysed throughout pregnancy and proposed as biomarkers of GDM. This study aimed to evaluate serum adiponectin, chemerin, lipocalin and apelin levels in GDM and non-GDM women, to assess them as clinically useful biomarkers of the occurrence of GDM and to demonstrate the correlation between the levels of the above adipokines in the blood serum and the increased risk of the development of GDM. The role of these adipokines in the pathogenesis of GDM was also analysed. The statistically significant differences between the levels of adiponectin (7234.6 vs. 9837.5 ng/mL, <i>p</i> < 0.0001), chemerin (264.0 vs. 206.7 ng/mL, <i>p</i> < 0.0001) and lipocalin (39.5 vs. 19.4 ng/mL, <i>p</i> < 0.0001) were observed between pregnant women with GDM and healthy ones. The diagnostic usefulness of the tested adipokines in detecting GDM was also assessed. The research results confirm the hypothesis on the significance of adiponectin, chemerin, lipocalin and apelin in the pathophysiological mechanisms of GDM. We speculate that these adipokines could potentially be established as novel biomarkers for the prediction and early diagnosis of GDM.https://www.mdpi.com/1422-0067/25/1/175gestational diabetes mellitusadipokinesadiponectinchemerinlipocalinapelin |
| spellingShingle | Maciej Kamiński Radzisław Mierzyński Elżbieta Poniedziałek-Czajkowska Agata Sadowska Maciej Sotowski Bożena Leszczyńska-Gorzelak Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus International Journal of Molecular Sciences gestational diabetes mellitus adipokines adiponectin chemerin lipocalin apelin |
| title | Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus |
| title_full | Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus |
| title_fullStr | Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus |
| title_full_unstemmed | Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus |
| title_short | Comparative Evaluation of Adipokine Metrics for the Diagnosis of Gestational Diabetes Mellitus |
| title_sort | comparative evaluation of adipokine metrics for the diagnosis of gestational diabetes mellitus |
| topic | gestational diabetes mellitus adipokines adiponectin chemerin lipocalin apelin |
| url | https://www.mdpi.com/1422-0067/25/1/175 |
| work_keys_str_mv | AT maciejkaminski comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus AT radzisławmierzynski comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus AT elzbietaponiedziałekczajkowska comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus AT agatasadowska comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus AT maciejsotowski comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus AT bozenaleszczynskagorzelak comparativeevaluationofadipokinemetricsforthediagnosisofgestationaldiabetesmellitus |