Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I
Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively. But unlike systemic CAIs, 2 % dorozolamide and 1 % brinzolamide penetrate deeply into the ocular tissues and do not c...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2020-11-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1315 |
| _version_ | 1797875400175517696 |
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| author | N. I. Kurysheva |
| author_facet | N. I. Kurysheva |
| author_sort | N. I. Kurysheva |
| collection | DOAJ |
| description | Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively. But unlike systemic CAIs, 2 % dorozolamide and 1 % brinzolamide penetrate deeply into the ocular tissues and do not cause systemic effects, so they are widely used in the treatment of glaucoma. The review characterizes various isoforms of carbonic anhydrase, considers the mechanisms of action of the drugs aimed at carbonic anhydrase blocking, and analyzes the results of various studies of 2 % dorzolamide and 1 % brinzolamide, as well as their fixed combinations. The effects of CAIs both as monotherapy and in combination with other antiglaucoma drugs are considered. The analysis of data on the effect of CAIs on ocular blood flow is presented. |
| first_indexed | 2024-04-10T01:47:03Z |
| format | Article |
| id | doaj.art-ba75755a3fbd454a8b3b6624079ef32f |
| institution | Directory Open Access Journal |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| last_indexed | 2024-04-10T01:47:03Z |
| publishDate | 2020-11-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj.art-ba75755a3fbd454a8b3b6624079ef32f2023-03-13T09:08:41ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452020-11-01173s54254910.18008/1816-5095-2020-3S-542-549668Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part IN. I. Kurysheva0Медико-биологический университет инноваций и непрерывного образования ФГБУ ГНЦ РФ «Федеральный биофизический центр им. А.И. Бурназяна» Федерального медико-биологического агентства России; Консультативно-диагностический отдел Центра офтальмологии Федерального медико-биологического агентства, клиническая больница № 86Glaucoma is the main cause of irreversible blindness in the world. Carbonic anhydrase inhibitors (CAIS) used both systemically and topically, reduce intraocular pressure effectively. But unlike systemic CAIs, 2 % dorozolamide and 1 % brinzolamide penetrate deeply into the ocular tissues and do not cause systemic effects, so they are widely used in the treatment of glaucoma. The review characterizes various isoforms of carbonic anhydrase, considers the mechanisms of action of the drugs aimed at carbonic anhydrase blocking, and analyzes the results of various studies of 2 % dorzolamide and 1 % brinzolamide, as well as their fixed combinations. The effects of CAIs both as monotherapy and in combination with other antiglaucoma drugs are considered. The analysis of data on the effect of CAIs on ocular blood flow is presented.https://www.ophthalmojournal.com/opht/article/view/1315ингибиторы карбоангидразыглаукомафиксированные комбинацииглазной кровоток |
| spellingShingle | N. I. Kurysheva Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I Oftalʹmologiâ ингибиторы карбоангидразы глаукома фиксированные комбинации глазной кровоток |
| title | Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I |
| title_full | Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I |
| title_fullStr | Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I |
| title_full_unstemmed | Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I |
| title_short | Carbonic Anhydrase Inhibitors in the Treatment of Glaucoma. Review. Part I |
| title_sort | carbonic anhydrase inhibitors in the treatment of glaucoma review part i |
| topic | ингибиторы карбоангидразы глаукома фиксированные комбинации глазной кровоток |
| url | https://www.ophthalmojournal.com/opht/article/view/1315 |
| work_keys_str_mv | AT nikurysheva carbonicanhydraseinhibitorsinthetreatmentofglaucomareviewparti |