An Adverse Outcome Pathway for Decreased Lung Function Focusing on Mechanisms of Impaired Mucociliary Clearance Following Inhalation Exposure

An Adverse Outcome Pathway for Decreased Lung Function Focusing on Mechanisms of Impaired Mucociliary Clearance Following Inhalation Exposure

Adverse outcome pathways (AOPs) help to organize available mechanistic information related to an adverse outcome into key events (KEs) spanning all organizational levels of a biological system(s). AOPs, therefore, aid in the biological understanding of a particular pathogenesis and also help with li...

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Bibliographic Details
Main Authors: Karsta Luettich, Monita Sharma, Hasmik Yepiskoposyan, Damien Breheny, Frazer J. Lowe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Toxicology
Subjects:
adverse outcome pathway
AOP
mucociliary clearance
ciliary beat frequency
lung function
new approach methodologies
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2021.750254/full

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