SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19
Objectives: We previously reported that SARS-CoV-2 infects the gastrointestinal (GI) epithelium. In this study, we aimed to explore the impact of SARS-CoV-2 GI infection on clinical outcomes of COVID-19.Materials and Methods: For this retrospective cohort study, 104 patients with COVID-19 were class...
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| Format: | Article |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.683551/full |
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| author | Zhijie Xu Zhijie Xu Zhijie Xu Meiwen Tang Meiwen Tang Meiwen Tang Ping Chen Hongyu Cai Fei Xiao Fei Xiao Fei Xiao |
| author_facet | Zhijie Xu Zhijie Xu Zhijie Xu Meiwen Tang Meiwen Tang Meiwen Tang Ping Chen Hongyu Cai Fei Xiao Fei Xiao Fei Xiao |
| author_sort | Zhijie Xu |
| collection | DOAJ |
| description | Objectives: We previously reported that SARS-CoV-2 infects the gastrointestinal (GI) epithelium. In this study, we aimed to explore the impact of SARS-CoV-2 GI infection on clinical outcomes of COVID-19.Materials and Methods: For this retrospective cohort study, 104 patients with COVID-19 were classified into a SARS-CoV-2 GI infection group and a non-infection group. The primary endpoint was the time of negative conversion of SARS-CoV-2 RNA in respiratory tract samples. The secondary outcome was the time of hospitalization for COVID-19.Results: Patients with SARS-CoV-2 GI infection had a longer duration of positive SARS-CoV-2 RNA in respiratory tract samples (median 12.0 days [95% CI: 10.0–13.2] vs. 9.0 days [95% CI: 7.5–10.5]; HR 0.575 [95% CI: 0.386–0.857]; P = 0.003) and hospitalization (median 28.0 days [95% CI: 23.2–32.8] vs. 15.0 days [95% CI: 13.6–16.4]; HR 0.149 [95% CI: 0.087–0.252]; P < 0.001) than patients without SARS-CoV-2 GI infection. Subgroup analyses for sex, age, epidemiological history, clinical classification and antiviral treatment showed consistent results.Conclusion: Our study indicates that SARS-CoV-2 GI infection prolongs the duration of SARS-CoV-2 shedding and hospitalization in the patients with COVID-19. More attention should be paid to SARS-CoV-2 GI infection of COVID-19 and fecal SARS-CoV-2 RNA test should be completed in time. |
| first_indexed | 2024-12-18T01:25:50Z |
| format | Article |
| id | doaj.art-ba75a3b7718d4d49b1c0005c1dd89439 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-18T01:25:50Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-ba75a3b7718d4d49b1c0005c1dd894392022-12-21T21:25:45ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-06-01810.3389/fmed.2021.683551683551SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19Zhijie Xu0Zhijie Xu1Zhijie Xu2Meiwen Tang3Meiwen Tang4Meiwen Tang5Ping Chen6Hongyu Cai7Fei Xiao8Fei Xiao9Fei Xiao10Department of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Hematology, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaDepartment of Infectious Diseases, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaGuangdong Provincial Engineering Research Center of Molecular Imaging, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, ChinaObjectives: We previously reported that SARS-CoV-2 infects the gastrointestinal (GI) epithelium. In this study, we aimed to explore the impact of SARS-CoV-2 GI infection on clinical outcomes of COVID-19.Materials and Methods: For this retrospective cohort study, 104 patients with COVID-19 were classified into a SARS-CoV-2 GI infection group and a non-infection group. The primary endpoint was the time of negative conversion of SARS-CoV-2 RNA in respiratory tract samples. The secondary outcome was the time of hospitalization for COVID-19.Results: Patients with SARS-CoV-2 GI infection had a longer duration of positive SARS-CoV-2 RNA in respiratory tract samples (median 12.0 days [95% CI: 10.0–13.2] vs. 9.0 days [95% CI: 7.5–10.5]; HR 0.575 [95% CI: 0.386–0.857]; P = 0.003) and hospitalization (median 28.0 days [95% CI: 23.2–32.8] vs. 15.0 days [95% CI: 13.6–16.4]; HR 0.149 [95% CI: 0.087–0.252]; P < 0.001) than patients without SARS-CoV-2 GI infection. Subgroup analyses for sex, age, epidemiological history, clinical classification and antiviral treatment showed consistent results.Conclusion: Our study indicates that SARS-CoV-2 GI infection prolongs the duration of SARS-CoV-2 shedding and hospitalization in the patients with COVID-19. More attention should be paid to SARS-CoV-2 GI infection of COVID-19 and fecal SARS-CoV-2 RNA test should be completed in time.https://www.frontiersin.org/articles/10.3389/fmed.2021.683551/fullSARS-CoV-2gastrointestinal infectionadverse effectstool viral loadalimentary tract |
| spellingShingle | Zhijie Xu Zhijie Xu Zhijie Xu Meiwen Tang Meiwen Tang Meiwen Tang Ping Chen Hongyu Cai Fei Xiao Fei Xiao Fei Xiao SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 Frontiers in Medicine SARS-CoV-2 gastrointestinal infection adverse effect stool viral load alimentary tract |
| title | SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 |
| title_full | SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 |
| title_fullStr | SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 |
| title_full_unstemmed | SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 |
| title_short | SARS-CoV-2 Gastrointestinal Infection Prolongs the Time to Recover From COVID-19 |
| title_sort | sars cov 2 gastrointestinal infection prolongs the time to recover from covid 19 |
| topic | SARS-CoV-2 gastrointestinal infection adverse effect stool viral load alimentary tract |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.683551/full |
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