Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases

Negative regulator NLRC3: Its potential role and regulatory mechanism in immune response and immune-related diseases

NLRC3 is a member of the pattern recognition receptors nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) family, and plays a pivotal regulatory role in modulating the activation of immune cells. In macrophages, NLRC3 inhibits the activation of the NF-κB signaling pathway, the STI...

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Bibliographic Details
Main Authors: Deyi Sun, Jiqian Xu, Wanying Zhang, Chaoying Song, Chenggang Gao, Yajun He, You Shang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
NLRC3
NOD-like receptor
NF-κB
sting
pyroptosis
PI3K
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1012459/full

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