IgG in the control of FcεRI activation: a battle on multiple fronts
The rising global incidence of IgE-mediated allergic reactions poses a significant challenge to the quality of life of affected individuals and to healthcare systems, with current treatments being limited in effectiveness, safety, and disease-modifying capabilities. IgE acts by sensitizing the high-...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1339171/full |
| _version_ | 1797357723271036928 |
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| author | Federico Storni Federico Storni Monique Vogel Monique Vogel Martin F. Bachmann Martin F. Bachmann Paul Engeroff Paul Engeroff |
| author_facet | Federico Storni Federico Storni Monique Vogel Monique Vogel Martin F. Bachmann Martin F. Bachmann Paul Engeroff Paul Engeroff |
| author_sort | Federico Storni |
| collection | DOAJ |
| description | The rising global incidence of IgE-mediated allergic reactions poses a significant challenge to the quality of life of affected individuals and to healthcare systems, with current treatments being limited in effectiveness, safety, and disease-modifying capabilities. IgE acts by sensitizing the high-affinity IgE receptor FcεRI expressed by mast cells and basophils, tuning these cells for inflammatory degranulation in response to future allergen encounters. In recent years, IgG has emerged as an essential negative regulator of IgE-dependent allergic inflammation. Mechanistically, studies have proposed different pathways by which IgG can interfere with the activation of IgE-mediated inflammation. Here, we briefly summarize the major proposed mechanisms of action by which IgG controls the IgE-FcεRI inflammatory axis and how those mechanisms are currently applied as therapeutic interventions for IgE-mediated inflammation. |
| first_indexed | 2024-03-08T14:49:16Z |
| format | Article |
| id | doaj.art-ba77a043962c47d3991436105c44b29e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T14:49:16Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ba77a043962c47d3991436105c44b29e2024-01-11T04:52:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-01-011410.3389/fimmu.2023.13391711339171IgG in the control of FcεRI activation: a battle on multiple frontsFederico Storni0Federico Storni1Monique Vogel2Monique Vogel3Martin F. Bachmann4Martin F. Bachmann5Paul Engeroff6Paul Engeroff7Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of BioMedical Research, University of Bern, Bern, SwitzerlandDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Rheumatology and Immunology, University Hospital Bern, Bern, SwitzerlandDepartment of BioMedical Research, University of Bern, Bern, SwitzerlandDepartment of Rheumatology and Immunology, University Hospital Bern, Bern, SwitzerlandDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, SwitzerlandDepartment of Rheumatology and Immunology, University Hospital Bern, Bern, SwitzerlandThe rising global incidence of IgE-mediated allergic reactions poses a significant challenge to the quality of life of affected individuals and to healthcare systems, with current treatments being limited in effectiveness, safety, and disease-modifying capabilities. IgE acts by sensitizing the high-affinity IgE receptor FcεRI expressed by mast cells and basophils, tuning these cells for inflammatory degranulation in response to future allergen encounters. In recent years, IgG has emerged as an essential negative regulator of IgE-dependent allergic inflammation. Mechanistically, studies have proposed different pathways by which IgG can interfere with the activation of IgE-mediated inflammation. Here, we briefly summarize the major proposed mechanisms of action by which IgG controls the IgE-FcεRI inflammatory axis and how those mechanisms are currently applied as therapeutic interventions for IgE-mediated inflammation.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1339171/fullallergyIgEmast cellsbasophilsdegranulationFcγRIIB |
| spellingShingle | Federico Storni Federico Storni Monique Vogel Monique Vogel Martin F. Bachmann Martin F. Bachmann Paul Engeroff Paul Engeroff IgG in the control of FcεRI activation: a battle on multiple fronts Frontiers in Immunology allergy IgE mast cells basophils degranulation FcγRIIB |
| title | IgG in the control of FcεRI activation: a battle on multiple fronts |
| title_full | IgG in the control of FcεRI activation: a battle on multiple fronts |
| title_fullStr | IgG in the control of FcεRI activation: a battle on multiple fronts |
| title_full_unstemmed | IgG in the control of FcεRI activation: a battle on multiple fronts |
| title_short | IgG in the control of FcεRI activation: a battle on multiple fronts |
| title_sort | igg in the control of fcεri activation a battle on multiple fronts |
| topic | allergy IgE mast cells basophils degranulation FcγRIIB |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1339171/full |
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