Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions
Abstract Purpose The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images with and without attenuation correction (Tomo-AC and Tomo-NoAC) compared wit...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2023-07-01
|
| Series: | EJNMMI Physics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40658-023-00566-3 |
| _version_ | 1797752642079817728 |
|---|---|
| author | Benjamin Serrano Régis Amblard Tiffany Beaumont Florent Hugonnet Matthieu Dietz Frédéric Berthier Nicolas Garnier Rémy Villeneuve Valérie Nataf François Mocquot Christopher Montemagno Marc Faraggi Benoît Paulmier |
| author_facet | Benjamin Serrano Régis Amblard Tiffany Beaumont Florent Hugonnet Matthieu Dietz Frédéric Berthier Nicolas Garnier Rémy Villeneuve Valérie Nataf François Mocquot Christopher Montemagno Marc Faraggi Benoît Paulmier |
| author_sort | Benjamin Serrano |
| collection | DOAJ |
| description | Abstract Purpose The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images with and without attenuation correction (Tomo-AC and Tomo-NoAC) compared with Planar acquisition in a series of 23 consecutive patients. The secondary objective was to determine radiation doses for the tracer administration and for the additional Computed Tomography (CT) scan. Methods Cross-calibration factors were determined using a thyroid phantom, for Planar, Tomo-AC and Tomo-NoAC images. Then Planar and SPECT/CT acquisitions centered on the thyroid were performed on 5 anthropomorphic phantoms with activity ranging from 0.4 to 10 MBq, and 23 patients after administration of 79.2 ± 3.7 MBq of [99mTc]-pertechnetate. We estimated the absolute thyroid activity (AThA) for the anthropomorphic phantoms and the TU for the patients. Radiation dose was also determined using International Commission on Radiological Protection (ICRP) reports and VirtualDoseTMCT software. Results Cross-calibration factors were 66.2 ± 4.9, 60.7 ± 0.7 and 26.5 ± 0.3 counts/(MBq s), respectively, for Planar, Tomo-AC and Tomo-NoAC images. Theoretical and estimated AThA for Planar, Tomo-AC and Tomo-NoAC images were statistically highly correlated (r < 0.99; P < 10–4) and the average of the relative percentage difference between theoretical and estimated AThA were (8.6 ± 17.8), (− 1.3 ± 5.2) and (12.8 ± 5.7) %, respectively. Comparisons between TU based on different pairs of images (Planar vs Tomo-AC, Planar vs Tomo-NoAC and Tomo-AC vs Tomo-NoAC) showed statistically significant correlation (r = 0.972, 0.961 and 0.935, respectively; P < 10–3). Effective and thyroid absorbed doses were, respectively (0.34CT + 0.95NM) mSv, and (3.88CT + 1.74NM) mGy. Conclusion AThA estimation using Planar and SPECT/CT acquisitions on a new generation of CZT large-field cameras is feasible. In addition, TU on SPECT/CT was as accurate as conventional planar acquisition, but the CT induced additional thyroid exposure. Trial registration Name of the registry: Thyroid Uptake Quantification on a New Generation of Gamma Camera (QUANTHYC). Trial number: NCT05049551. Registered September 20, 2021—Retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT05049551?cntry=MC&draw=2&rank=4 . |
| first_indexed | 2024-03-12T17:06:23Z |
| format | Article |
| id | doaj.art-ba7903fb51a944fe8f70f0d78d7fd6c2 |
| institution | Directory Open Access Journal |
| issn | 2197-7364 |
| language | English |
| last_indexed | 2024-03-12T17:06:23Z |
| publishDate | 2023-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | EJNMMI Physics |
| spelling | doaj.art-ba7903fb51a944fe8f70f0d78d7fd6c22023-08-06T11:25:08ZengSpringerOpenEJNMMI Physics2197-73642023-07-0110111610.1186/s40658-023-00566-3Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitionsBenjamin Serrano0Régis Amblard1Tiffany Beaumont2Florent Hugonnet3Matthieu Dietz4Frédéric Berthier5Nicolas Garnier6Rémy Villeneuve7Valérie Nataf8François Mocquot9Christopher Montemagno10Marc Faraggi11Benoît Paulmier12Medical Physics Department, Centre Hospitalier Princesse GraceMedical Physics Department, Centre Hospitalier Princesse GraceLaboratoire d’évaluation de la dose interne, Institut de Radioprotection et de Sûreté NucléaireNuclear Medicine Department, Centre Hospitalier Princesse GraceNuclear Medicine Department, Hospices Civils de LyonDepartment of Biostatistics, Centre Hospitalier Princesse GraceMedical Physics Department, Centre Hospitalier Princesse GraceMedical Physics Department, Centre Hospitalier Princesse GraceNuclear Medicine Department, Centre Hospitalier Princesse GraceNuclear Medicine Department, Centre Hospitalier Princesse GraceDepartment of Medical Biology, Centre Scientifique de MonacoNuclear Medicine Department, Centre Hospitalier Princesse GraceNuclear Medicine Department, Centre Hospitalier Princesse GraceAbstract Purpose The main objective of this study was to evaluate the ability of a large field Cadmium Zinc Telluride (CZT) camera to estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images with and without attenuation correction (Tomo-AC and Tomo-NoAC) compared with Planar acquisition in a series of 23 consecutive patients. The secondary objective was to determine radiation doses for the tracer administration and for the additional Computed Tomography (CT) scan. Methods Cross-calibration factors were determined using a thyroid phantom, for Planar, Tomo-AC and Tomo-NoAC images. Then Planar and SPECT/CT acquisitions centered on the thyroid were performed on 5 anthropomorphic phantoms with activity ranging from 0.4 to 10 MBq, and 23 patients after administration of 79.2 ± 3.7 MBq of [99mTc]-pertechnetate. We estimated the absolute thyroid activity (AThA) for the anthropomorphic phantoms and the TU for the patients. Radiation dose was also determined using International Commission on Radiological Protection (ICRP) reports and VirtualDoseTMCT software. Results Cross-calibration factors were 66.2 ± 4.9, 60.7 ± 0.7 and 26.5 ± 0.3 counts/(MBq s), respectively, for Planar, Tomo-AC and Tomo-NoAC images. Theoretical and estimated AThA for Planar, Tomo-AC and Tomo-NoAC images were statistically highly correlated (r < 0.99; P < 10–4) and the average of the relative percentage difference between theoretical and estimated AThA were (8.6 ± 17.8), (− 1.3 ± 5.2) and (12.8 ± 5.7) %, respectively. Comparisons between TU based on different pairs of images (Planar vs Tomo-AC, Planar vs Tomo-NoAC and Tomo-AC vs Tomo-NoAC) showed statistically significant correlation (r = 0.972, 0.961 and 0.935, respectively; P < 10–3). Effective and thyroid absorbed doses were, respectively (0.34CT + 0.95NM) mSv, and (3.88CT + 1.74NM) mGy. Conclusion AThA estimation using Planar and SPECT/CT acquisitions on a new generation of CZT large-field cameras is feasible. In addition, TU on SPECT/CT was as accurate as conventional planar acquisition, but the CT induced additional thyroid exposure. Trial registration Name of the registry: Thyroid Uptake Quantification on a New Generation of Gamma Camera (QUANTHYC). Trial number: NCT05049551. Registered September 20, 2021—Retrospectively registered, https://clinicaltrials.gov/ct2/show/record/NCT05049551?cntry=MC&draw=2&rank=4 .https://doi.org/10.1186/s40658-023-00566-3ThyroidAbsolute activityUptakeQuantificationCZTPlanar |
| spellingShingle | Benjamin Serrano Régis Amblard Tiffany Beaumont Florent Hugonnet Matthieu Dietz Frédéric Berthier Nicolas Garnier Rémy Villeneuve Valérie Nataf François Mocquot Christopher Montemagno Marc Faraggi Benoît Paulmier Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions EJNMMI Physics Thyroid Absolute activity Uptake Quantification CZT Planar |
| title | Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions |
| title_full | Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions |
| title_fullStr | Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions |
| title_full_unstemmed | Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions |
| title_short | Quantitative analysis of 99mTc-pertechnetate thyroid uptake with a large-field CZT gamma camera: feasibility and comparison between SPECT/CT and planar acquisitions |
| title_sort | quantitative analysis of 99mtc pertechnetate thyroid uptake with a large field czt gamma camera feasibility and comparison between spect ct and planar acquisitions |
| topic | Thyroid Absolute activity Uptake Quantification CZT Planar |
| url | https://doi.org/10.1186/s40658-023-00566-3 |
| work_keys_str_mv | AT benjaminserrano quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT regisamblard quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT tiffanybeaumont quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT florenthugonnet quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT matthieudietz quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT fredericberthier quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT nicolasgarnier quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT remyvilleneuve quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT valerienataf quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT francoismocquot quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT christophermontemagno quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT marcfaraggi quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions AT benoitpaulmier quantitativeanalysisof99mtcpertechnetatethyroiduptakewithalargefieldcztgammacamerafeasibilityandcomparisonbetweenspectctandplanaracquisitions |