Overexpressed HIF-2α in Endothelial Cells Promotes Vascularization and Improves Random Pattern Skin Flap Survival

Overexpressed HIF-2α in Endothelial Cells Promotes Vascularization and Improves Random Pattern Skin Flap Survival

Background: The local skin flap procedure is very useful for reconstruction. However, flap necrosis caused by circulatory failure can occur at its distal portion. Hypoxia-inducible factors (HIFs) in endothelial cells (ECs) help to maintain ECs and promote vascularization, and HIF-2α is abundantly ex...

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Main Authors: Atsushi Morimoto, MD, Shuhei Tomita, MD, PhD, Masaki Imanishi, MS, Go Shioi, PhD, Yoshitaka Kihira, PhD, Yuki Izawa-Ishizawa, MD, PhD, Mitsuru Takaku, MD, PhD, Ichiro Hashimoto, MD, PhD, Yasumasa Ikeda, MD, PhD, Hideki Nakanishi, MD, PhD, Toshiaki Tamaki, MD, PhD
Format: Article
Language:English
Published: Wolters Kluwer 2014-04-01
Series:Plastic and Reconstructive Surgery, Global Open
Online Access:http://journals.lww.com/prsgo/Fulltext/2014/04000/Article.10.aspx

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