Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity
Abstract Background The aim of this study was to evaluate the efficacy and safety of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study. Methods Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsqu...
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| Format: | Article |
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Wiley
2019-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2408 |
| _version_ | 1818514230235627520 |
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| author | Hiroaki Ikawa Masashi Koto Yusuke Demizu Jun‐ichi Saitoh Hiroaki Suefuji Tomoaki Okimoto Tatsuya Ohno Yoshiyuki Shioyama Ryo Takagi Kazuhiko Hayashi Kenji Nemoto Takashi Nakano Tadashi Kamada |
| author_facet | Hiroaki Ikawa Masashi Koto Yusuke Demizu Jun‐ichi Saitoh Hiroaki Suefuji Tomoaki Okimoto Tatsuya Ohno Yoshiyuki Shioyama Ryo Takagi Kazuhiko Hayashi Kenji Nemoto Takashi Nakano Tadashi Kamada |
| author_sort | Hiroaki Ikawa |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to evaluate the efficacy and safety of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study. Methods Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0‐1 M0 status and were treated with carbon‐ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed. Results Salivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1‐3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow‐up period was 31.1 months (range, 3‐118 months). Three‐year local control, progression‐free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed. Conclusions Oral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon‐ion radiation therapy. |
| first_indexed | 2024-12-11T00:12:55Z |
| format | Article |
| id | doaj.art-ba7c1d94ea9f4f4c9e6351b455166cd7 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-11T00:12:55Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-ba7c1d94ea9f4f4c9e6351b455166cd72022-12-22T01:28:04ZengWileyCancer Medicine2045-76342019-09-018125482549110.1002/cam4.2408Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavityHiroaki Ikawa0Masashi Koto1Yusuke Demizu2Jun‐ichi Saitoh3Hiroaki Suefuji4Tomoaki Okimoto5Tatsuya Ohno6Yoshiyuki Shioyama7Ryo Takagi8Kazuhiko Hayashi9Kenji Nemoto10Takashi Nakano11Tadashi Kamada12Hospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Sciences and Technology Chiba JapanHospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Sciences and Technology Chiba JapanDepartment of Radiology Hyogo Ion Beam Medical Center Tatsuno JapanGunma University Heavy Ion Medical Center Maebashi JapanIon Beam Therapy Center SAGA‐HIMAT Foundation Tosu JapanDepartment of Radiology Hyogo Ion Beam Medical Center Tatsuno JapanGunma University Heavy Ion Medical Center Maebashi JapanIon Beam Therapy Center SAGA‐HIMAT Foundation Tosu JapanDepartment of Oral Pathobiological Science and Surgery Tokyo Dental College Tokyo JapanHospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Sciences and Technology Chiba JapanDepartment of Radiation Oncology, Faculty of Medicine Yamagata University Yamagata JapanGunma University Heavy Ion Medical Center Maebashi JapanHospital of the National Institute of Radiological Sciences National Institutes for Quantum and Radiological Sciences and Technology Chiba JapanAbstract Background The aim of this study was to evaluate the efficacy and safety of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity in a multicenter study. Methods Retrospective analysis of the clinicopathological features and outcomes of 76 patients with oral nonsquamous cell carcinomas with N0‐1 M0 status and were treated with carbon‐ion radiation therapy at four institutions in Japan between November 2003 and December 2014 was performed. Results Salivary gland carcinoma, mucosal melanoma, and three other carcinomas were found in 46, 27, and 3 patients, respectively. T1‐3, T4a, and T4b disease was diagnosed in 27, 18, and 31 patients, respectively. Median follow‐up period was 31.1 months (range, 3‐118 months). Three‐year local control, progression‐free survival, and overall survival of all patients were 86.8%, 63.1%, and 78.4%, respectively. Multivariate analysis showed T classification (T4) to be a significant independent poor prognostic factor for local control. Acute grade 3 mucositis was observed in 38 patients. Grades 3 and 4 late morbidities were observed in 9 and 4 patients, respectively. No grade 5 late toxicity was observed. Conclusions Oral nonsquamous cell carcinomas could be treated effectively, with acceptable toxicity, by carbon‐ion radiation therapy.https://doi.org/10.1002/cam4.2408adenoid cystic carcinomacarbon‐ion radiotherapyhead and neck canceroral cancerosteoradionecrosisparticle therapy |
| spellingShingle | Hiroaki Ikawa Masashi Koto Yusuke Demizu Jun‐ichi Saitoh Hiroaki Suefuji Tomoaki Okimoto Tatsuya Ohno Yoshiyuki Shioyama Ryo Takagi Kazuhiko Hayashi Kenji Nemoto Takashi Nakano Tadashi Kamada Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity Cancer Medicine adenoid cystic carcinoma carbon‐ion radiotherapy head and neck cancer oral cancer osteoradionecrosis particle therapy |
| title | Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| title_full | Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| title_fullStr | Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| title_full_unstemmed | Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| title_short | Multicenter study of carbon‐ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| title_sort | multicenter study of carbon ion radiation therapy for nonsquamous cell carcinomas of the oral cavity |
| topic | adenoid cystic carcinoma carbon‐ion radiotherapy head and neck cancer oral cancer osteoradionecrosis particle therapy |
| url | https://doi.org/10.1002/cam4.2408 |
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