The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis
Abstract Background To explore the efficacy and safety of minocycline as adjuvant therapy for refractory mycoplasma pneumonia in Chinese children. Methods PubMed, EMBASE, Cochrane Library, CNKI, Wanfang database and VIP database were systematically searched. Studies where minocycline was used as adj...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-09-01
|
| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-022-01362-y |
| _version_ | 1811258936497537024 |
|---|---|
| author | Hong-Xia Shen Chang Liu Hui-Jun Lin Lu-Jie Xu Guang-Yan Wang Mei-Xing Yan |
| author_facet | Hong-Xia Shen Chang Liu Hui-Jun Lin Lu-Jie Xu Guang-Yan Wang Mei-Xing Yan |
| author_sort | Hong-Xia Shen |
| collection | DOAJ |
| description | Abstract Background To explore the efficacy and safety of minocycline as adjuvant therapy for refractory mycoplasma pneumonia in Chinese children. Methods PubMed, EMBASE, Cochrane Library, CNKI, Wanfang database and VIP database were systematically searched. Studies where minocycline was used as adjuvant therapy for refractory mycoplasma pneumonia in Chinese children were included. The effect of numeration data and the measurement data were represented by odds ratios (OR) and weighted mean differences (MD), respectively. Review Manager version 5.3 was used to compare the treatment efficacy, time for the cough to subside, defervescence time, hospitalisation time, adverse events and other indicators. Results Ten studies involving 857 patients were included in the final analysis. Compared with the conventional treatment of refractory mycoplasma pneumonia in children, the addition of minocycline as adjuvant therapy was found to improve the treatment efficacy (OR: 5.45; 95% CI: 3.46, 8.57, p < 0.001); shorten the duration of cough (MD: -3.61; 95%CI: -4.25, -2.97, p < 0.001), fever time (MD: -4.77; 95% CI: -6.30, -3.23, p < 0.001) and hospitalisation time (MD: -5.53 (95% CI: -7.19, -3.88, p < 0.001); and decrease the concentration of C-reactive protein (MD: -13.95; 95%CI: -18.61, -9.29; p < 0.001) and the erythrocyte sedimentation rate (MD: -10.88; 95% CI: -14.05, -7.72, p < 0.001). The use of minocycline did not lead to significant adverse events (OR = 0.63; 95% CI: 0.39, 1.01, p = 0.05). Conclusion The use of minocycline as adjuvant treatment of refractory mycoplasma pneumonia in Chinese children has good efficacy and safety and may be promoted in clinical practice. |
| first_indexed | 2024-04-12T18:22:59Z |
| format | Article |
| id | doaj.art-ba7c67360f82480ea0c93171cb08a5a8 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-04-12T18:22:59Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-ba7c67360f82480ea0c93171cb08a5a82022-12-22T03:21:22ZengBMCItalian Journal of Pediatrics1824-72882022-09-0148111010.1186/s13052-022-01362-yThe efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysisHong-Xia Shen0Chang Liu1Hui-Jun Lin2Lu-Jie Xu3Guang-Yan Wang4Mei-Xing Yan5Department of Pharmacy, Women and Children’s Hospital, Qingdao UniversityDepartment of Pharmacy, Women and Children’s Hospital, Qingdao UniversityDepartment of Pharmacy, Women and Children’s Hospital, Qingdao UniversityDepartment of Pharmacy, Women and Children’s Hospital, Qingdao UniversityDepartment of Pharmacy, Women and Children’s Hospital, Qingdao UniversityDepartment of Pharmacy, Women and Children’s Hospital, Qingdao UniversityAbstract Background To explore the efficacy and safety of minocycline as adjuvant therapy for refractory mycoplasma pneumonia in Chinese children. Methods PubMed, EMBASE, Cochrane Library, CNKI, Wanfang database and VIP database were systematically searched. Studies where minocycline was used as adjuvant therapy for refractory mycoplasma pneumonia in Chinese children were included. The effect of numeration data and the measurement data were represented by odds ratios (OR) and weighted mean differences (MD), respectively. Review Manager version 5.3 was used to compare the treatment efficacy, time for the cough to subside, defervescence time, hospitalisation time, adverse events and other indicators. Results Ten studies involving 857 patients were included in the final analysis. Compared with the conventional treatment of refractory mycoplasma pneumonia in children, the addition of minocycline as adjuvant therapy was found to improve the treatment efficacy (OR: 5.45; 95% CI: 3.46, 8.57, p < 0.001); shorten the duration of cough (MD: -3.61; 95%CI: -4.25, -2.97, p < 0.001), fever time (MD: -4.77; 95% CI: -6.30, -3.23, p < 0.001) and hospitalisation time (MD: -5.53 (95% CI: -7.19, -3.88, p < 0.001); and decrease the concentration of C-reactive protein (MD: -13.95; 95%CI: -18.61, -9.29; p < 0.001) and the erythrocyte sedimentation rate (MD: -10.88; 95% CI: -14.05, -7.72, p < 0.001). The use of minocycline did not lead to significant adverse events (OR = 0.63; 95% CI: 0.39, 1.01, p = 0.05). Conclusion The use of minocycline as adjuvant treatment of refractory mycoplasma pneumonia in Chinese children has good efficacy and safety and may be promoted in clinical practice.https://doi.org/10.1186/s13052-022-01362-yMinocyclineMycoplasma pneumoniaChinese children |
| spellingShingle | Hong-Xia Shen Chang Liu Hui-Jun Lin Lu-Jie Xu Guang-Yan Wang Mei-Xing Yan The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis Italian Journal of Pediatrics Minocycline Mycoplasma pneumonia Chinese children |
| title | The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis |
| title_full | The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis |
| title_fullStr | The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis |
| title_full_unstemmed | The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis |
| title_short | The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a meta-analysis |
| title_sort | efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in chinese children a meta analysis |
| topic | Minocycline Mycoplasma pneumonia Chinese children |
| url | https://doi.org/10.1186/s13052-022-01362-y |
| work_keys_str_mv | AT hongxiashen theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT changliu theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT huijunlin theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT lujiexu theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT guangyanwang theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT meixingyan theefficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT hongxiashen efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT changliu efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT huijunlin efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT lujiexu efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT guangyanwang efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis AT meixingyan efficacyandsafetyofminocyclineasadjuvanttherapyinrefractorymycoplasmapneumoniainchinesechildrenametaanalysis |