Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH

Chakraborty et al. show that phagocyte NADPH oxidase (NOX2) collapses the ΔpH of intracellular Salmonella Typhimurium, leading to oxidative damage of cell envelope proteins. Salmonella responds by shifting redox balance from respiration to glycolysis and fermentation, thereby facilitating folding of...

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Bibliographic Details
Main Authors:	Sangeeta Chakraborty, Lin Liu, Liam Fitzsimmons, Steffen Porwollik, Ju-Sim Kim, Prerak Desai, Michael McClelland, Andres Vazquez-Torres
Format:	Article
Language:	English
Published:	Nature Portfolio 2020-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15604-2

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