Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study
In the South Korean study to prevent cognitive impairment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on white matter integrity. Among 152 pa...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1242295/full |
| _version_ | 1797679250968412160 |
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| author | Sun Min Lee Sohui Kim Jee Hyang Jeong Chang Hyung Hong Yoo Kyoung Park Hae Ri Na Hong-Sun Song Hee Kyung Park Muncheong Choi Buong-O Chun Seong Hye Choi Jong-Min Lee So Young Moon |
| author_facet | Sun Min Lee Sohui Kim Jee Hyang Jeong Chang Hyung Hong Yoo Kyoung Park Hae Ri Na Hong-Sun Song Hee Kyung Park Muncheong Choi Buong-O Chun Seong Hye Choi Jong-Min Lee So Young Moon |
| author_sort | Sun Min Lee |
| collection | DOAJ |
| description | In the South Korean study to prevent cognitive impairment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on white matter integrity. Among 152 participants, aged 60–79 years without dementia but with ≥1 modifiable dementia risk factor, 19 FMI, 20 HMI, and 16 controls underwent brain MRI at baseline and 24 weeks. Between the intervention and control groups, we compared changes in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) at regions-of-interest (ROI) including the cingulum cingulate gyrus (CgC), cingulum hippocampus (CgH), superior longitudinal fasciculus (SLF), as well as the uncinate fasciculus (UF). In addition, correlations between total and standard scores cognitive domains of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) or serum brain-derived neurotrophic factor (BDNF) and changes in brain image measures were evaluated at a statistical significance level of p < 0.05 (uncorrected for multiple corrections). The FA, MD, AD, and RD at each ROI at the baseline were not different among groups after Bonferroni correction. In the statistical analysis using two-way repeated measures ANOVA, any significant difference in longitudinal changes in the FA, MD, AD, and RD was not revealed. The statistical analysis, among the significant regions in paired t-test of the intervention group, compared with the control group, the FMI, HMI, and intervention group yielded significantly more beneficial effects on the AD of the CgC. In addition, longitudinal AD changes of the left CgC correlated with the BDNF changes (r = 0.280, p = 0.048). In this study, enhanced cognitive reserve after the multidomain lifestyle intervention could be revealed by changes in brain imaging for white matter integrity. |
| first_indexed | 2024-03-11T23:11:48Z |
| format | Article |
| id | doaj.art-ba7fb94faad7468d8c3dd2c44064dad0 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-11T23:11:48Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ba7fb94faad7468d8c3dd2c44064dad02023-09-21T08:17:29ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-09-011510.3389/fnagi.2023.12422951242295Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-studySun Min Lee0Sohui Kim1Jee Hyang Jeong2Chang Hyung Hong3Yoo Kyoung Park4Hae Ri Na5Hong-Sun Song6Hee Kyung Park7Muncheong Choi8Buong-O Chun9Seong Hye Choi10Jong-Min Lee11So Young Moon12Department of Neurology, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Electronic Engineering, Hanyang University, Seoul, Republic of KoreaDepartment of Neurology, Ewha Womans University School of Medicine, Seoul, Republic of KoreaDepartment of Psychiatry, Ajou University School of Medicine, Suwon, Republic of KoreaDepartment of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University, Suwon, Republic of KoreaDepartment of Neurology, Bobath Memorial Hospital, Seongnam, Republic of KoreaDepartment of Sports Sciences, Korea Institute of Sports Science, Seoul, Republic of KoreaDivision of Psychiatry, University College London, London, United KingdomExercowork, Seoul, Republic of Korea0Graduate School of Physical Education, College of Arts and Physical Education, Myongji University, Yongin, Republic of Korea1Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea2Department of Biomedical Engineering, Hanyang University, Seoul, Republic of KoreaDepartment of Neurology, Ajou University School of Medicine, Suwon, Republic of KoreaIn the South Korean study to prevent cognitive impairment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), we evaluated the impact of a 24-week facility-based multidomain intervention (FMI) and home-based MI (HMI) on white matter integrity. Among 152 participants, aged 60–79 years without dementia but with ≥1 modifiable dementia risk factor, 19 FMI, 20 HMI, and 16 controls underwent brain MRI at baseline and 24 weeks. Between the intervention and control groups, we compared changes in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) at regions-of-interest (ROI) including the cingulum cingulate gyrus (CgC), cingulum hippocampus (CgH), superior longitudinal fasciculus (SLF), as well as the uncinate fasciculus (UF). In addition, correlations between total and standard scores cognitive domains of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) or serum brain-derived neurotrophic factor (BDNF) and changes in brain image measures were evaluated at a statistical significance level of p < 0.05 (uncorrected for multiple corrections). The FA, MD, AD, and RD at each ROI at the baseline were not different among groups after Bonferroni correction. In the statistical analysis using two-way repeated measures ANOVA, any significant difference in longitudinal changes in the FA, MD, AD, and RD was not revealed. The statistical analysis, among the significant regions in paired t-test of the intervention group, compared with the control group, the FMI, HMI, and intervention group yielded significantly more beneficial effects on the AD of the CgC. In addition, longitudinal AD changes of the left CgC correlated with the BDNF changes (r = 0.280, p = 0.048). In this study, enhanced cognitive reserve after the multidomain lifestyle intervention could be revealed by changes in brain imaging for white matter integrity.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1242295/fullwhite matter integritycingulum cingulate gyrusdementiapreventionlifestyleintervention |
| spellingShingle | Sun Min Lee Sohui Kim Jee Hyang Jeong Chang Hyung Hong Yoo Kyoung Park Hae Ri Na Hong-Sun Song Hee Kyung Park Muncheong Choi Buong-O Chun Seong Hye Choi Jong-Min Lee So Young Moon Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study Frontiers in Aging Neuroscience white matter integrity cingulum cingulate gyrus dementia prevention lifestyle intervention |
| title | Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study |
| title_full | Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study |
| title_fullStr | Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study |
| title_full_unstemmed | Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study |
| title_short | Impact of a multidomain lifestyle intervention on white matter integrity: the SUPERBRAIN exploratory sub-study |
| title_sort | impact of a multidomain lifestyle intervention on white matter integrity the superbrain exploratory sub study |
| topic | white matter integrity cingulum cingulate gyrus dementia prevention lifestyle intervention |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1242295/full |
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