High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study
Objectives: This study aimed to assess the efficacy of praziquantel in reducing urinary schistosomiasis prevalence, parasite burden and morbidity rates among a previously reported sample of Schistosoma haematobium-infected children. In addition, predisposing factors for reinfection one year post-tre...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sultan Qaboos University
2018-12-01
|
| Series: | Sultan Qaboos University Medical Journal |
| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/2850 |
| _version_ | 1830207163173175296 |
|---|---|
| author | Robert S. Houmsou Binga E. Wama Hemen Agere John A. Uniga Elizabeth U. Amuta Santaya L. Kela |
| author_facet | Robert S. Houmsou Binga E. Wama Hemen Agere John A. Uniga Elizabeth U. Amuta Santaya L. Kela |
| author_sort | Robert S. Houmsou |
| collection | DOAJ |
| description | Objectives: This study aimed to assess the efficacy of praziquantel in reducing urinary schistosomiasis prevalence, parasite burden and morbidity rates among a previously reported sample of Schistosoma haematobium-infected children. In addition, predisposing factors for reinfection one year post-treatment were also determined. Methods: This prospective follow-up study was conducted between March 2014 and February 2015 among 675 previously reported children with urinary schistosomiasis in the Murbai and Surbai communities of Ardo Kola, Taraba State, Nigeria. A single dose of 40 mg/kg of praziquantel was administered to each infected child, with a second dose administered one month later if necessary. The number of S. haematobium eggs in urine samples was calculated at baseline and post-treatment. Results: At four weeks post-treatment, the overall cure rate was 98.1%. Among children with low and heavy parasite burdens at baseline, egg reduction rates (ERRs) were 100% and 96.5%, respectively. The vast majority of children with microhaematuria (98.7%) and proteinuria (98.6%) at baseline were cured at follow-up. Following a second dose, the ERR, overall and morbidity cure rates increased to 100%. At one year post-treatment, 272 infected children (40.3%) were re-assessed; of these, 51 children (18.8%) were reinfected. Close proximity to bodies of water (odds ratio [OR] = 1.23, 95% confidence interval [CI]: 0.998–1.530; P = 0.05) and fishing (OR = 2.23, 95% CI: 0.828–6.040; P = 0.01) were significant factors that predisposed children to reinfection. Conclusion: A moderate rate of reinfection was noted. Governmental and nongovernmental organisations in Nigeria should collaborate on mass treatment and health education campaigns to reduce the incidence of urinary schistosomiasis reinfections.
Keywords: Urinary Schistosomiasis; Praziquantel; Treatment Outcome; Follow-Up Study; Nigeria. |
| first_indexed | 2024-12-18T04:27:36Z |
| format | Article |
| id | doaj.art-ba808c1f6d6644f699e64f8a318c74e9 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-12-18T04:27:36Z |
| publishDate | 2018-12-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-ba808c1f6d6644f699e64f8a318c74e92022-12-21T21:21:05ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282018-12-0118330431010.18295/squmj.2018.18.03.0072456High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up studyRobert S. Houmsou0Binga E. Wama1Hemen Agere2John A. Uniga3Elizabeth U. Amuta4Santaya L. Kela5Department of Biological Sciences, Taraba State University, Jalingo, Taraba State, NigeriaDepartment of Biological Sciences, Taraba State University, Jalingo, Taraba State, NigeriaDepartment of Biological Sciences, Faculty of Pure & Applied Sciences, Federal University Wukari, Taraba State, NigeriaPaediatrics Unit, Federal Medical Centre, Jalingo, Taraba State, NigeriaDepartment of Biological Sciences, University of Agriculture, Makurdi, Benue State, NigeriaDepartment of Biological Sciences, Federal University of Kachere, Kashere, Gombe State, NigeriaObjectives: This study aimed to assess the efficacy of praziquantel in reducing urinary schistosomiasis prevalence, parasite burden and morbidity rates among a previously reported sample of Schistosoma haematobium-infected children. In addition, predisposing factors for reinfection one year post-treatment were also determined. Methods: This prospective follow-up study was conducted between March 2014 and February 2015 among 675 previously reported children with urinary schistosomiasis in the Murbai and Surbai communities of Ardo Kola, Taraba State, Nigeria. A single dose of 40 mg/kg of praziquantel was administered to each infected child, with a second dose administered one month later if necessary. The number of S. haematobium eggs in urine samples was calculated at baseline and post-treatment. Results: At four weeks post-treatment, the overall cure rate was 98.1%. Among children with low and heavy parasite burdens at baseline, egg reduction rates (ERRs) were 100% and 96.5%, respectively. The vast majority of children with microhaematuria (98.7%) and proteinuria (98.6%) at baseline were cured at follow-up. Following a second dose, the ERR, overall and morbidity cure rates increased to 100%. At one year post-treatment, 272 infected children (40.3%) were re-assessed; of these, 51 children (18.8%) were reinfected. Close proximity to bodies of water (odds ratio [OR] = 1.23, 95% confidence interval [CI]: 0.998–1.530; P = 0.05) and fishing (OR = 2.23, 95% CI: 0.828–6.040; P = 0.01) were significant factors that predisposed children to reinfection. Conclusion: A moderate rate of reinfection was noted. Governmental and nongovernmental organisations in Nigeria should collaborate on mass treatment and health education campaigns to reduce the incidence of urinary schistosomiasis reinfections. Keywords: Urinary Schistosomiasis; Praziquantel; Treatment Outcome; Follow-Up Study; Nigeria.https://journals.squ.edu.om/index.php/squmj/article/view/2850 |
| spellingShingle | Robert S. Houmsou Binga E. Wama Hemen Agere John A. Uniga Elizabeth U. Amuta Santaya L. Kela High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study Sultan Qaboos University Medical Journal |
| title | High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study |
| title_full | High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study |
| title_fullStr | High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study |
| title_full_unstemmed | High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study |
| title_short | High Efficacy of Praziquantel in Schistosoma haematobium-Infected Children in Taraba State, Northeast Nigeria: A follow-up study |
| title_sort | high efficacy of praziquantel in schistosoma haematobium infected children in taraba state northeast nigeria a follow up study |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/2850 |
| work_keys_str_mv | AT robertshoumsou highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy AT bingaewama highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy AT hemenagere highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy AT johnauniga highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy AT elizabethuamuta highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy AT santayalkela highefficacyofpraziquantelinschistosomahaematobiuminfectedchildrenintarabastatenortheastnigeriaafollowupstudy |