A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning
Abstract Background Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relations...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Gastroenterology |
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| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01291-2 |
| _version_ | 1818414927476424704 |
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| author | Craig Friesen Meenal Singh Vivekanand Singh Jennifer V. Schurman |
| author_facet | Craig Friesen Meenal Singh Vivekanand Singh Jennifer V. Schurman |
| author_sort | Craig Friesen |
| collection | DOAJ |
| description | Abstract Background Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. A secondary aim was to assess relationships between nausea and other gastrointestinal symptoms, non-gastrointestinal somatic symptoms, and psychological dysfunction. Methods Records from patients with pain associated functional gastrointestinal disorders were retrospectively reviewed for gastrointestinal and somatic symptoms and anxiety, depression, and somatizations scores as assessed by the Behavior Assessment System for Children (BASC-2). In addition, previous gastric and mucosal biopsies were assessed for mast cell and eosinophil densities, respectively. Results 250 patients, ages 8 to 17 years, were assessed. Nausea was reported by 78% and was equally prevalent in those with FD alone, those with IBS alone, and those with both FD and IBS. Nausea was associated with increased mean (21.4 vs. 17.5) and peak (26.2 vs. 22.9) duodenal mast cell densities as compared those without nausea. Nausea was also associated with a wide variety of individual gastrointestinal symptoms, as well as headaches, fatigue, and dizziness. Lastly, nausea was associated with elevated self-report scores for anxiety (55.2 vs. 50.0), depression (50.2 vs. 46.1), and somatization (70.3 vs. 61.8). Conclusions Nausea is common in children and adolescents with pain-associated FGIDs as defined by Rome IV and is not unique to either FD or IBS. Nausea is associated with increased mucosal mast cell density, non-gastrointestinal somatic symptoms, and psychologic dysfunction. |
| first_indexed | 2024-12-14T11:26:52Z |
| format | Article |
| id | doaj.art-ba80951f7cd94b09896f60dfaeaa8437 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-14T11:26:52Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-ba80951f7cd94b09896f60dfaeaa84372022-12-21T23:03:31ZengBMCBMC Gastroenterology1471-230X2020-05-012011610.1186/s12876-020-01291-2A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioningCraig Friesen0Meenal Singh1Vivekanand Singh2Jennifer V. Schurman3Division of Gastroenterology, Hepatology, and Nutrition, Children’s Mercy Kansas CityDivision of Gastroenterology, Hepatology, and Nutrition, Children’s Mercy Kansas CityDepartment of Pathology and Laboratory Medicine, Children’s Mercy Kansas CityDivision of Developmental and Behavioral Sciences, Children’s Mercy Kansas CityAbstract Background Nausea is a common symptom in youth with chronic abdominal pain. The aims of the current study were to assess: 1) the frequency of nausea in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), respectively, as defined by Rome IV criteria; and, 2) relationships between nausea and mucosal inflammation as defined by antral and duodenal eosinophil and mast cell densities. A secondary aim was to assess relationships between nausea and other gastrointestinal symptoms, non-gastrointestinal somatic symptoms, and psychological dysfunction. Methods Records from patients with pain associated functional gastrointestinal disorders were retrospectively reviewed for gastrointestinal and somatic symptoms and anxiety, depression, and somatizations scores as assessed by the Behavior Assessment System for Children (BASC-2). In addition, previous gastric and mucosal biopsies were assessed for mast cell and eosinophil densities, respectively. Results 250 patients, ages 8 to 17 years, were assessed. Nausea was reported by 78% and was equally prevalent in those with FD alone, those with IBS alone, and those with both FD and IBS. Nausea was associated with increased mean (21.4 vs. 17.5) and peak (26.2 vs. 22.9) duodenal mast cell densities as compared those without nausea. Nausea was also associated with a wide variety of individual gastrointestinal symptoms, as well as headaches, fatigue, and dizziness. Lastly, nausea was associated with elevated self-report scores for anxiety (55.2 vs. 50.0), depression (50.2 vs. 46.1), and somatization (70.3 vs. 61.8). Conclusions Nausea is common in children and adolescents with pain-associated FGIDs as defined by Rome IV and is not unique to either FD or IBS. Nausea is associated with increased mucosal mast cell density, non-gastrointestinal somatic symptoms, and psychologic dysfunction.http://link.springer.com/article/10.1186/s12876-020-01291-2Functional dyspepsiaIrritable bowel syndromeMast cellsAnxietySomatization |
| spellingShingle | Craig Friesen Meenal Singh Vivekanand Singh Jennifer V. Schurman A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning BMC Gastroenterology Functional dyspepsia Irritable bowel syndrome Mast cells Anxiety Somatization |
| title | A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning |
| title_full | A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning |
| title_fullStr | A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning |
| title_full_unstemmed | A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning |
| title_short | A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning |
| title_sort | cross sectional study of nausea in functional abdominal pain relation to mucosal mast cells and psychological functioning |
| topic | Functional dyspepsia Irritable bowel syndrome Mast cells Anxiety Somatization |
| url | http://link.springer.com/article/10.1186/s12876-020-01291-2 |
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