A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy

A novel cocktail therapy based on quintuplet combination of oncolytic herpes simplex virus-2 vectors armed with interleukin-12, interleukin-15, GM-CSF, PD1v, and IL-7 × CCL19 results in enhanced antitumor efficacy

Abstract Background Selectively replicating herpes simplex virus-2 (HSV-2) vector is a promising treatment for cancer therapy. The insertion of multiple transgenes into the viral genome has been performed to improve its oncolytic activity. Methods Herein, we simultaneously constructed five “armed” o...

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Bibliographic Details
Main Authors: Han Hu, Siqi Zhang, Linkang Cai, Haixiao Duan, Yuying Li, Junhan Yang, Yang Wang, Biao Liu, Shuang Dong, Zhizheng Fang, Binlei Liu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Virology Journal
Subjects:
Oncolytic herpes simplex virus
Combined therapy
4T1
CT26
Online Access:https://doi.org/10.1186/s12985-022-01795-1

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