Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

Osteosarcoma-enriched transcripts paradoxically generate osteosarcoma-suppressing extracellular proteins

Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-derived proteomes and OS-elevated proteins. While a conditioned me...

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Bibliographic Details
Main Authors: Kexin Li, Qingji Huo, Nathan H Dimmitt, Guofan Qu, Junjie Bao, Pankita H Pandya, M Reza Saadatzadeh, Khadijeh Bijangi-Vishehsaraei, Melissa A Kacena, Karen E Pollok, Chien-Chi Lin, Bai-Yan Li, Hiroki Yokota
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-03-01
Series:eLife
Subjects:
osteosarcoma
MSC
proteome
calreticulin
CD47
PCOLCE
Online Access:https://elifesciences.org/articles/83768

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