Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea
Erysipelas, caused by Erysipelothrix rhusiopathiae, is considered one of the most serious infectious diseases of captive and free-ranging cetaceans worldwide, as these animals are known to be highly susceptible to the bacterial infections. The potential diversity between E. rhusiopathiae isolates fr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.774836/full |
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| author | Kyunglee Lee Seon Young Park Hwi Won Seo Yuna Cho Seok-Gwan Choi Seunghyun Seo Wonmin Han Nam-Kyung Lee Hyemin Kwon Jee Eun Han Ji Hyung Kim Ji Hyung Kim |
| author_facet | Kyunglee Lee Seon Young Park Hwi Won Seo Yuna Cho Seok-Gwan Choi Seunghyun Seo Wonmin Han Nam-Kyung Lee Hyemin Kwon Jee Eun Han Ji Hyung Kim Ji Hyung Kim |
| author_sort | Kyunglee Lee |
| collection | DOAJ |
| description | Erysipelas, caused by Erysipelothrix rhusiopathiae, is considered one of the most serious infectious diseases of captive and free-ranging cetaceans worldwide, as these animals are known to be highly susceptible to the bacterial infections. The potential diversity between E. rhusiopathiae isolates from captive cetaceans has been previously described; however, the microbiological features of the free-ranging cetacean isolates remain unclear. Here, we describe a case of bacteremia in a rough-toothed dolphin (Steno bredanensis) caused by E. rhusiopathiae. Additionally, we present the first genomic features of the bacteria from free-ranging cetacean individuals. Histopathological and microbial examinations revealed that E. rhusiopathiae caused bacteremia and systemic infection in the dolphin. The genome of the isolated E. rhusiopathiae strain KC-Sb-R1, which was classified as Clade 1 possessing SpaB gene, was clearly differentiated from the other swine-isolated E. rhusiopathiae, and the comparison of its serovar-defining chromosomal region revealed that our isolate was greatly similar to those of other previously reported serovar 2/15 isolates, including the captive-dolphin isolate. Moreover, most of the potential virulence factors in the strain KC-Sb-R1 were similar to those in the strain Fujisawa. Further, a potential cytotoxicity of the isolate was confirmed, suggesting that marine mammal-isolated E. rhusiopathiae could possess strong pathogenic potential in other animals, including humans. These results would further increase our understanding on the risk factors for controlling zoonotic pathogens of emerging infectious diseases in captive or free-ranging cetaceans, and also provide important insight into the diversity of E. rhusiopathiae in animals. |
| first_indexed | 2024-12-12T14:05:23Z |
| format | Article |
| id | doaj.art-ba8348d53c594a81bc31ef0967babbe2 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-12T14:05:23Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-ba8348d53c594a81bc31ef0967babbe22022-12-22T00:22:14ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-05-01910.3389/fvets.2022.774836774836Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in KoreaKyunglee Lee0Seon Young Park1Hwi Won Seo2Yuna Cho3Seok-Gwan Choi4Seunghyun Seo5Wonmin Han6Nam-Kyung Lee7Hyemin Kwon8Jee Eun Han9Ji Hyung Kim10Ji Hyung Kim11Cetacean Research Institute, National Institute of Fisheries Science, Ulsan, South KoreaInfectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South KoreaInfectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South KoreaCetacean Research Institute, National Institute of Fisheries Science, Ulsan, South KoreaCetacean Research Institute, National Institute of Fisheries Science, Ulsan, South KoreaAquaplanet Co. Ltd., Seoul, South KoreaAquaplanet Co. Ltd., Seoul, South KoreaBiotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South KoreaInfectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South KoreaCollege of Veterinary Medicine, Kyungpook National University, Daegu, South KoreaInfectious Diseases Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South KoreaDepartment of Food Science and Biotechnology, Gachon University, Seongnam, South KoreaErysipelas, caused by Erysipelothrix rhusiopathiae, is considered one of the most serious infectious diseases of captive and free-ranging cetaceans worldwide, as these animals are known to be highly susceptible to the bacterial infections. The potential diversity between E. rhusiopathiae isolates from captive cetaceans has been previously described; however, the microbiological features of the free-ranging cetacean isolates remain unclear. Here, we describe a case of bacteremia in a rough-toothed dolphin (Steno bredanensis) caused by E. rhusiopathiae. Additionally, we present the first genomic features of the bacteria from free-ranging cetacean individuals. Histopathological and microbial examinations revealed that E. rhusiopathiae caused bacteremia and systemic infection in the dolphin. The genome of the isolated E. rhusiopathiae strain KC-Sb-R1, which was classified as Clade 1 possessing SpaB gene, was clearly differentiated from the other swine-isolated E. rhusiopathiae, and the comparison of its serovar-defining chromosomal region revealed that our isolate was greatly similar to those of other previously reported serovar 2/15 isolates, including the captive-dolphin isolate. Moreover, most of the potential virulence factors in the strain KC-Sb-R1 were similar to those in the strain Fujisawa. Further, a potential cytotoxicity of the isolate was confirmed, suggesting that marine mammal-isolated E. rhusiopathiae could possess strong pathogenic potential in other animals, including humans. These results would further increase our understanding on the risk factors for controlling zoonotic pathogens of emerging infectious diseases in captive or free-ranging cetaceans, and also provide important insight into the diversity of E. rhusiopathiae in animals.https://www.frontiersin.org/articles/10.3389/fvets.2022.774836/fullClade 1free-ranging cetaceansgenomeserovar 2/15zoonotic pathogens |
| spellingShingle | Kyunglee Lee Seon Young Park Hwi Won Seo Yuna Cho Seok-Gwan Choi Seunghyun Seo Wonmin Han Nam-Kyung Lee Hyemin Kwon Jee Eun Han Ji Hyung Kim Ji Hyung Kim Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea Frontiers in Veterinary Science Clade 1 free-ranging cetaceans genome serovar 2/15 zoonotic pathogens |
| title | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea |
| title_full | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea |
| title_fullStr | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea |
| title_full_unstemmed | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea |
| title_short | Pathological and Genomic Findings of Erysipelothrix rhusiopathiae Isolated From a Free-Ranging Rough-Toothed Dolphin Steno bredanensis (Cetacea: Delphinidae) Stranded in Korea |
| title_sort | pathological and genomic findings of erysipelothrix rhusiopathiae isolated from a free ranging rough toothed dolphin steno bredanensis cetacea delphinidae stranded in korea |
| topic | Clade 1 free-ranging cetaceans genome serovar 2/15 zoonotic pathogens |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.774836/full |
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