A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

A newly developed oxime K203 is the most effective reactivator of tabun-inhibited acetylcholinesterase

Abstract Background Based on in vitro and in vivo rat experiments, the newly developed acetylcholinesterase (AChE) reactivator, K203, appears to be much more effective in the treatment of tabun poisonings than currently fielded oximes. Methods To determine if this reactivating efficacy would extend...

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Bibliographic Details
Main Authors: Kamil Kuca, Kamil Musilek, Daniel Jun, Jana Zdarova-Karasova, Eugenie Nepovimova, Ondrej Soukup, Martina Hrabinova, John Mikler, Tanos C. C. Franca, Elaine F. F. Da Cunha, Alexandre A. De Castro, Martin Valis, Teodorico C. Ramalho
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Pharmacology and Toxicology
Subjects:
Antidotes
Chemical warfare agents
Poisoning
Treatment
Reactivator
Oxime
Online Access:http://link.springer.com/article/10.1186/s40360-018-0196-3

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