Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat
Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an alread...
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| Format: | Article |
| Language: | English |
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The Pan African Medical Journal
2019-03-01
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| Series: | The Pan African Medical Journal |
| Subjects: | |
| Online Access: |
https://www.panafrican-med-journal.com/content/article/32/105/pdf/105.pdf
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| _version_ | 1819003628679069696 |
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| author | Farhan Fazal Nitin Gupta Shivabalan Kathavarayan Ramu Aditya Nayan Naval Kishore Vikram Animesh Ray |
| author_facet | Farhan Fazal Nitin Gupta Shivabalan Kathavarayan Ramu Aditya Nayan Naval Kishore Vikram Animesh Ray |
| author_sort | Farhan Fazal |
| collection | DOAJ |
| description | Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction. |
| first_indexed | 2024-12-20T23:24:02Z |
| format | Article |
| id | doaj.art-ba845a8d388c432a858b074f3e4746e1 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-20T23:24:02Z |
| publishDate | 2019-03-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-ba845a8d388c432a858b074f3e4746e12022-12-21T19:23:26ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882019-03-013210510.11604/pamj.2019.32.105.1476414764Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treatFarhan Fazal0Nitin Gupta1Shivabalan Kathavarayan Ramu2Aditya Nayan3Naval Kishore Vikram4Animesh Ray5 Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Department of Medicine, All India Institute of Medical Sciences, New Delhi, India Haemophagocytic lymphohistiocytosis (HLH) in Human Immunodeficiency Virus (HIV) infected individuals can either be due to the disease itself or due to associated infections/malignancies. The treatment for HLH requires immunosuppressive therapy but administering immunosuppressive therapy to an already immunosuppressed patient (HIV infection) is complex. We present two such cases of HLH in patients infected with HIV. In the first case, no alternate cause for HLH was found even after extensive investigations and it was attributed to the uncontrolled HIV replication. Patient was started on dexamethasone for the same but succumbed to hospital acquired pneumonia. The second patient was diagnosed with Hodgkin's lymphoma but he succumbed to his illness before initiating immunosuppressive therapy for HLH. We report these cases to highlight the dilemma and a need for further research in this direction. https://www.panafrican-med-journal.com/content/article/32/105/pdf/105.pdf malignancysteroidshospital acquired pneumonia |
| spellingShingle | Farhan Fazal Nitin Gupta Shivabalan Kathavarayan Ramu Aditya Nayan Naval Kishore Vikram Animesh Ray Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat The Pan African Medical Journal malignancy steroids hospital acquired pneumonia |
| title | Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat |
| title_full | Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat |
| title_fullStr | Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat |
| title_full_unstemmed | Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat |
| title_short | Haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection: to treat or not to treat |
| title_sort | haemophagocytic lymphohistiocytosis in patients with human immunodeficiency virus infection to treat or not to treat |
| topic | malignancy steroids hospital acquired pneumonia |
| url |
https://www.panafrican-med-journal.com/content/article/32/105/pdf/105.pdf
|
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