Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes
Platelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after blood vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common in ovarian cancer patients and is associated with poor clinical...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/4/1282 |
| _version_ | 1797621877827436544 |
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| author | Selin Oncul Min Soon Cho |
| author_facet | Selin Oncul Min Soon Cho |
| author_sort | Selin Oncul |
| collection | DOAJ |
| description | Platelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after blood vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common in ovarian cancer patients and is associated with poor clinical outcomes. Platelets extravasate into the tumor microenvironment in ovarian cancer and interact with cancer cells and non-cancerous elements. Ovarian cancer cells also activate platelets. The communication between activated platelets, cancer cells, and the tumor microenvironment is via various platelet membrane proteins or mediators released through degranulation or the secretion of microvesicles from platelets. These interactions trigger signaling cascades in tumors that promote ovarian cancer progression, metastasis, and neoangiogenesis. This review discusses how interactions between platelets, cancer cells, cancer stem cells, stromal cells, and the extracellular matrix in the tumor microenvironment influence ovarian cancer progression. It also presents novel potential therapeutic approaches toward this gynecological cancer. |
| first_indexed | 2024-03-11T09:02:17Z |
| format | Article |
| id | doaj.art-ba87180f2aeb41f18f66b2e441d42354 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:02:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ba87180f2aeb41f18f66b2e441d423542023-11-16T19:38:49ZengMDPI AGCancers2072-66942023-02-01154128210.3390/cancers15041282Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical OutcomesSelin Oncul0Min Soon Cho1Section of Benign Hematology, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USASection of Benign Hematology, Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAPlatelets, the primary operatives of hemostasis that contribute to blood coagulation and wound healing after blood vessel injury, are also involved in pathological conditions, including cancer. Malignancy-associated thrombosis is common in ovarian cancer patients and is associated with poor clinical outcomes. Platelets extravasate into the tumor microenvironment in ovarian cancer and interact with cancer cells and non-cancerous elements. Ovarian cancer cells also activate platelets. The communication between activated platelets, cancer cells, and the tumor microenvironment is via various platelet membrane proteins or mediators released through degranulation or the secretion of microvesicles from platelets. These interactions trigger signaling cascades in tumors that promote ovarian cancer progression, metastasis, and neoangiogenesis. This review discusses how interactions between platelets, cancer cells, cancer stem cells, stromal cells, and the extracellular matrix in the tumor microenvironment influence ovarian cancer progression. It also presents novel potential therapeutic approaches toward this gynecological cancer.https://www.mdpi.com/2072-6694/15/4/1282ovarian cancerplatelettumor microenvironmentmetastasisangiogenesisthrombosis |
| spellingShingle | Selin Oncul Min Soon Cho Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes Cancers ovarian cancer platelet tumor microenvironment metastasis angiogenesis thrombosis |
| title | Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes |
| title_full | Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes |
| title_fullStr | Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes |
| title_full_unstemmed | Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes |
| title_short | Interactions between Platelets and Tumor Microenvironment Components in Ovarian Cancer and Their Implications for Treatment and Clinical Outcomes |
| title_sort | interactions between platelets and tumor microenvironment components in ovarian cancer and their implications for treatment and clinical outcomes |
| topic | ovarian cancer platelet tumor microenvironment metastasis angiogenesis thrombosis |
| url | https://www.mdpi.com/2072-6694/15/4/1282 |
| work_keys_str_mv | AT selinoncul interactionsbetweenplateletsandtumormicroenvironmentcomponentsinovariancancerandtheirimplicationsfortreatmentandclinicaloutcomes AT minsooncho interactionsbetweenplateletsandtumormicroenvironmentcomponentsinovariancancerandtheirimplicationsfortreatmentandclinicaloutcomes |