Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles
Abstract In this study, it was aimed to introduce a transdermal drug delivery system with dissolving microneedles (DMNs) based on gelatin (GEL) and sodium carboxymethyl cellulose (NaCMC) for lidocaine hydrochloride (LidoHCl) delivery. Different ratios of GEL and NaCMC were mixed, loaded with an acti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-04-01
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| Series: | AAPS Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41120-023-00074-9 |
| _version_ | 1797849989963055104 |
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| author | Shabnam Bahmani Ramin Khajavi Morteza Ehsani Mohammad Karim Rahimi Mohammad Reza Kalaee |
| author_facet | Shabnam Bahmani Ramin Khajavi Morteza Ehsani Mohammad Karim Rahimi Mohammad Reza Kalaee |
| author_sort | Shabnam Bahmani |
| collection | DOAJ |
| description | Abstract In this study, it was aimed to introduce a transdermal drug delivery system with dissolving microneedles (DMNs) based on gelatin (GEL) and sodium carboxymethyl cellulose (NaCMC) for lidocaine hydrochloride (LidoHCl) delivery. Different ratios of GEL and NaCMC were mixed, loaded with an active agent of LidoHCl, and treated with glutaraldehyde (GTA) as a crosslinker agent. Prepared hydrogels were cast into a silicon mold. Hereby, microneedles (MNs) with 500 µm height, 35° needle angle, 40-µm tip radius, and 960-µm tip-to-tip distance were fabricated. Samples containing LidoHCl 40%, GEL/NaCMC 5:1 (wt/wt), and polymer/GTA ratio 3.1 (wt/wt) showed the highest drug release ability (t < 10 min) with proper mechanical properties in comparison with other samples. Due to the drug release in a short time (fewer than 10 min), this drug delivery system can be used for rapid local anesthesia for pain relief as well as before minor skin surgeries. Graphical Abstract |
| first_indexed | 2024-04-09T18:53:06Z |
| format | Article |
| id | doaj.art-ba87692f96214b9a9dcf006643c0d6fa |
| institution | Directory Open Access Journal |
| issn | 2364-9534 |
| language | English |
| last_indexed | 2024-04-09T18:53:06Z |
| publishDate | 2023-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | AAPS Open |
| spelling | doaj.art-ba87692f96214b9a9dcf006643c0d6fa2023-04-09T11:22:38ZengSpringerOpenAAPS Open2364-95342023-04-019111510.1186/s41120-023-00074-9Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedlesShabnam Bahmani0Ramin Khajavi1Morteza Ehsani2Mohammad Karim Rahimi3Mohammad Reza Kalaee4Department of Polymer Engineering, Faculty of Engineering, Islamic Azad University, South Tehran BranchDepartment of Polymer and Textile, Islamic Azad University, South Tehran BranchDepartment of Polymer Engineering, Faculty of Engineering, Islamic Azad University, South Tehran BranchDepartment of Medical, Tehran Medical Sciences Branch Islamic Azad UniversityDepartment of Polymer Engineering, Faculty of Engineering, Islamic Azad University, South Tehran BranchAbstract In this study, it was aimed to introduce a transdermal drug delivery system with dissolving microneedles (DMNs) based on gelatin (GEL) and sodium carboxymethyl cellulose (NaCMC) for lidocaine hydrochloride (LidoHCl) delivery. Different ratios of GEL and NaCMC were mixed, loaded with an active agent of LidoHCl, and treated with glutaraldehyde (GTA) as a crosslinker agent. Prepared hydrogels were cast into a silicon mold. Hereby, microneedles (MNs) with 500 µm height, 35° needle angle, 40-µm tip radius, and 960-µm tip-to-tip distance were fabricated. Samples containing LidoHCl 40%, GEL/NaCMC 5:1 (wt/wt), and polymer/GTA ratio 3.1 (wt/wt) showed the highest drug release ability (t < 10 min) with proper mechanical properties in comparison with other samples. Due to the drug release in a short time (fewer than 10 min), this drug delivery system can be used for rapid local anesthesia for pain relief as well as before minor skin surgeries. Graphical Abstracthttps://doi.org/10.1186/s41120-023-00074-9Dissolving microneedlesSodium carboxymethylcellulose/gelatin hydrogelsLidocaine hydrochloride |
| spellingShingle | Shabnam Bahmani Ramin Khajavi Morteza Ehsani Mohammad Karim Rahimi Mohammad Reza Kalaee Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles AAPS Open Dissolving microneedles Sodium carboxymethylcellulose/gelatin hydrogels Lidocaine hydrochloride |
| title | Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles |
| title_full | Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles |
| title_fullStr | Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles |
| title_full_unstemmed | Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles |
| title_short | Transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin/sodium carboxymethylcellulose microneedles |
| title_sort | transdermal drug delivery system of lidocaine hydrochloride based on dissolving gelatin sodium carboxymethylcellulose microneedles |
| topic | Dissolving microneedles Sodium carboxymethylcellulose/gelatin hydrogels Lidocaine hydrochloride |
| url | https://doi.org/10.1186/s41120-023-00074-9 |
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