The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches
Glioblastoma is the most prevalent primary brain tumour and invariably confers a poor prognosis. The immense intra-tumoral heterogeneity of glioblastoma and its ability to rapidly develop treatment resistance are key barriers to successful therapy. As such, there is an urgent need for the greater un...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/13/3307 |
| _version_ | 1797592086804955136 |
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| author | Simon Deacon Lauryn Walker Masar Radhi Stuart Smith |
| author_facet | Simon Deacon Lauryn Walker Masar Radhi Stuart Smith |
| author_sort | Simon Deacon |
| collection | DOAJ |
| description | Glioblastoma is the most prevalent primary brain tumour and invariably confers a poor prognosis. The immense intra-tumoral heterogeneity of glioblastoma and its ability to rapidly develop treatment resistance are key barriers to successful therapy. As such, there is an urgent need for the greater understanding of the tumour biology in order to guide the development of novel therapeutics in this field. N6-methyladenosine (m6A) is the most abundant of the RNA modifications in eukaryotes. Studies have demonstrated that the regulation of this RNA modification is altered in glioblastoma and may serve to regulate diverse mechanisms including glioma stem-cell self-renewal, tumorigenesis, invasion and treatment evasion. However, the precise mechanisms by which m6A modifications exert their functional effects are poorly understood. This review summarises the evidence for the disordered regulation of m6A in glioblastoma and discusses the downstream functional effects of m6A modification on RNA fate. The wide-ranging biological consequences of m6A modification raises the hope that novel cancer therapies can be targeted against this mechanism. |
| first_indexed | 2024-03-11T01:46:26Z |
| format | Article |
| id | doaj.art-ba87a4735c61456db6d1746ff1e5fe76 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:46:26Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ba87a4735c61456db6d1746ff1e5fe762023-11-18T16:15:05ZengMDPI AGCancers2072-66942023-06-011513330710.3390/cancers15133307The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic ApproachesSimon Deacon0Lauryn Walker1Masar Radhi2Stuart Smith3Children’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG7 2RD, UKChildren’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG7 2RD, UKChildren’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG7 2RD, UKChildren’s Brain Tumour Research Centre, University of Nottingham, Nottingham NG7 2RD, UKGlioblastoma is the most prevalent primary brain tumour and invariably confers a poor prognosis. The immense intra-tumoral heterogeneity of glioblastoma and its ability to rapidly develop treatment resistance are key barriers to successful therapy. As such, there is an urgent need for the greater understanding of the tumour biology in order to guide the development of novel therapeutics in this field. N6-methyladenosine (m6A) is the most abundant of the RNA modifications in eukaryotes. Studies have demonstrated that the regulation of this RNA modification is altered in glioblastoma and may serve to regulate diverse mechanisms including glioma stem-cell self-renewal, tumorigenesis, invasion and treatment evasion. However, the precise mechanisms by which m6A modifications exert their functional effects are poorly understood. This review summarises the evidence for the disordered regulation of m6A in glioblastoma and discusses the downstream functional effects of m6A modification on RNA fate. The wide-ranging biological consequences of m6A modification raises the hope that novel cancer therapies can be targeted against this mechanism.https://www.mdpi.com/2072-6694/15/13/3307glioblastomaepitranscriptomicsRNA methylation |
| spellingShingle | Simon Deacon Lauryn Walker Masar Radhi Stuart Smith The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches Cancers glioblastoma epitranscriptomics RNA methylation |
| title | The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches |
| title_full | The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches |
| title_fullStr | The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches |
| title_full_unstemmed | The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches |
| title_short | The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches |
| title_sort | regulation of m6a modification in glioblastoma functional mechanisms and therapeutic approaches |
| topic | glioblastoma epitranscriptomics RNA methylation |
| url | https://www.mdpi.com/2072-6694/15/13/3307 |
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