SESAME-catalyzed H3T11 phosphorylation inhibits Dot1-catalyzed H3K79me3 to regulate autophagy and telomere silencing
How H3T11 phosphorylation exerts biological functions remains poorly understood. Here, authors show that H3pT11 directly inhibits Dot1-catalyzed H3K79 tri-methylation (H3K79me3) and uncover how this histone crosstalk regulates autophagy and telomere silencing.
Main Authors: | Fei He, Qi Yu, Min Wang, Rongsha Wang, Xuanyunjing Gong, Feng Ge, Xilan Yu, Shanshan Li |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-12-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-35182-9 |
Similar Items
-
Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability
by: Xinyu Zhang, et al.
Published: (2023-07-01) -
In Vivo Identification of H3K9me2/H3K79me3 as an Epigenetic Barrier to Carcinogenesis
by: Maria Cristina Piro, et al.
Published: (2023-07-01) -
ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin
by: Vincent T Bicocca, et al.
Published: (2018-11-01) -
Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy
by: Qi Yu, et al.
Published: (2022-09-01) -
Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
by: Gianluca Teano, et al.
Published: (2023-08-01)