Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia
Background: The activity of angiotension converting enzyme (ACE; OMIM: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ACE in psychiatric disorders. Genetic polymorphism of insertion/deletion (I/D; dbSNP rs4646994) in the gene encoding...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2015-03-01
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| Series: | Iranian Journal of Public Health |
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| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/3642 |
| _version_ | 1818980702356504576 |
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| author | Hajar Mazaheri Mostafa Saadat |
| author_facet | Hajar Mazaheri Mostafa Saadat |
| author_sort | Hajar Mazaheri |
| collection | DOAJ |
| description | Background: The activity of angiotension converting enzyme (ACE; OMIM: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ACE in psychiatric disorders. Genetic polymorphism of insertion/deletion (I/D; dbSNP rs4646994) in the gene encoding ACE has been well defined.
Methods: The present case-control study was performed on 363 (268 males, 95 females) in-patients with schizophrenia diagnosis, and 363 (268 males, 95 females) healthy blood donor controls. The genotypes of I/D ACE polymorphism were determined using PCR method. PCR products were separated and sized by electrophoresis on a 2% agarose gel. The insertion allele (I) was detected as a 478 bp band, and the deletion allele (D) was visualized as a 191 bp band. The association between genotypes of the I/D polymorphism and the schizophrenia risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs).
Results: Among females, the II genotype significantly decreased the risk of schizophrenia compared with the DD genotype (OR=0.18, 95%CI: 0.04-0.72, P=0.015). There was significant linear trend for the number of the I allele and schizophrenia risk among females (Chi2=5.19, P=0.023). There was no significant association between I/D polymorphism and susceptibility to schizophrenia among male subjects. There was significant interaction between gender and the II genotype (P=0.031).
Conclusion: The II genotype of the I/D polymorphism has a protective effect for schizophrenia among females. |
| first_indexed | 2024-12-20T17:19:37Z |
| format | Article |
| id | doaj.art-ba8aaaeb03824130a69ec63f925acbcc |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-20T17:19:37Z |
| publishDate | 2015-03-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-ba8aaaeb03824130a69ec63f925acbcc2022-12-21T19:31:53ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932015-03-014433507Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to SchizophreniaHajar Mazaheri0Mostafa Saadat1Dept. of Biology, College of Sciences, Shiraz University, Shiraz, Iran.Institute of Biotechnology, Shiraz University, Shiraz, Iran.Background: The activity of angiotension converting enzyme (ACE; OMIM: 106180) in different brain regions of patients with schizophrenia changed, suggesting a possible involvement of ACE in psychiatric disorders. Genetic polymorphism of insertion/deletion (I/D; dbSNP rs4646994) in the gene encoding ACE has been well defined. Methods: The present case-control study was performed on 363 (268 males, 95 females) in-patients with schizophrenia diagnosis, and 363 (268 males, 95 females) healthy blood donor controls. The genotypes of I/D ACE polymorphism were determined using PCR method. PCR products were separated and sized by electrophoresis on a 2% agarose gel. The insertion allele (I) was detected as a 478 bp band, and the deletion allele (D) was visualized as a 191 bp band. The association between genotypes of the I/D polymorphism and the schizophrenia risk was examined by use of odds ratios (OR) and 95% of confidence intervals (CIs). Results: Among females, the II genotype significantly decreased the risk of schizophrenia compared with the DD genotype (OR=0.18, 95%CI: 0.04-0.72, P=0.015). There was significant linear trend for the number of the I allele and schizophrenia risk among females (Chi2=5.19, P=0.023). There was no significant association between I/D polymorphism and susceptibility to schizophrenia among male subjects. There was significant interaction between gender and the II genotype (P=0.031). Conclusion: The II genotype of the I/D polymorphism has a protective effect for schizophrenia among females.https://ijph.tums.ac.ir/index.php/ijph/article/view/3642Angiotensin converting enzymeIranian populationPolymorphismRiskSchizophrenia |
| spellingShingle | Hajar Mazaheri Mostafa Saadat Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia Iranian Journal of Public Health Angiotensin converting enzyme Iranian population Polymorphism Risk Schizophrenia |
| title | Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia |
| title_full | Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia |
| title_fullStr | Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia |
| title_full_unstemmed | Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia |
| title_short | Association between Insertion/Deletion Polymorphism in Angiotension Converting Enzyme and Susceptibility to Schizophrenia |
| title_sort | association between insertion deletion polymorphism in angiotension converting enzyme and susceptibility to schizophrenia |
| topic | Angiotensin converting enzyme Iranian population Polymorphism Risk Schizophrenia |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/3642 |
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