Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure
The aim – to evaluate the safety of mononuclear cord blood stem cells transplantation regarding influence upon heart rhythm in patients with refractory heart failure Materials and methods. The work is based on the analysis of Holter-ECG monitoring data in 20 patients with refractory heart failure a...
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| Format: | Article |
| Language: | English |
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TOV Chetverta Khvylia
2016-09-01
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| Series: | Кардіохірургія та інтервенційна кардіологія |
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| Online Access: | http://csic.com.ua/images/pdf/2016/3-2016/heart-rhythm-safety-mononuclear-cord-blood-stem-cells-transplantation.pdf |
| _version_ | 1826840824146558976 |
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| author | O.Yu. Usenko A.V. Yakushev O.V. Lisun M.V. Kostylev V.F. Onishchenko |
| author_facet | O.Yu. Usenko A.V. Yakushev O.V. Lisun M.V. Kostylev V.F. Onishchenko |
| author_sort | O.Yu. Usenko |
| collection | DOAJ |
| description | The aim – to evaluate the safety of mononuclear cord blood stem cells transplantation regarding influence upon heart rhythm in patients with refractory heart failure
Materials and methods. The work is based on the analysis of Holter-ECG monitoring data in 20 patients with refractory heart failure and reduced myocardial contractility. With the purpose of improvement of systolic function patients underwent transplantation of mononuclear cord blood stem cells.
Results. Analysis of the probable proarrhythmogenic influence of mononuclear cord blood stem cells was performed in terms of follow-up during up to 9 months. Results demonstrated that administration of the cell preparation «Cryopreserved human cord blood» is not associated with increased risk of life-threatening cardiac arrhythmias.
Conclusions.Transplantation of mononuclear cord blood stem cells should not be considered as an additional arrhythmogenic risk factor in patients with refractory heart failure. |
| first_indexed | 2024-12-12T19:15:56Z |
| format | Article |
| id | doaj.art-ba8b40a4f54b4290b03e15197cf78bed |
| institution | Directory Open Access Journal |
| issn | 2305-3127 |
| language | English |
| last_indexed | 2025-02-16T12:48:38Z |
| publishDate | 2016-09-01 |
| publisher | TOV Chetverta Khvylia |
| record_format | Article |
| series | Кардіохірургія та інтервенційна кардіологія |
| spelling | doaj.art-ba8b40a4f54b4290b03e15197cf78bed2025-02-02T21:02:55ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272016-09-013 (14)1520Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failureO.Yu. Usenko0A.V. Yakushev1O.V. Lisun2M.V. Kostylev3V.F. Onishchenko4O.O. Shalimov National Institute of Surgery and Transplantology of NAMS of Ukraine, Kyiv, UkraineO.O. Shalimov National Institute of Surgery and Transplantology of NAMS of Ukraine, Kyiv, UkraineO.O. Shalimov National Institute of Surgery and Transplantology of NAMS of Ukraine, Kyiv, UkraineO.O. Shalimov National Institute of Surgery and Transplantology of NAMS of Ukraine, Kyiv, UkraineO.O. Shalimov National Institute of Surgery and Transplantology of NAMS of Ukraine, Kyiv, UkraineThe aim – to evaluate the safety of mononuclear cord blood stem cells transplantation regarding influence upon heart rhythm in patients with refractory heart failure Materials and methods. The work is based on the analysis of Holter-ECG monitoring data in 20 patients with refractory heart failure and reduced myocardial contractility. With the purpose of improvement of systolic function patients underwent transplantation of mononuclear cord blood stem cells. Results. Analysis of the probable proarrhythmogenic influence of mononuclear cord blood stem cells was performed in terms of follow-up during up to 9 months. Results demonstrated that administration of the cell preparation «Cryopreserved human cord blood» is not associated with increased risk of life-threatening cardiac arrhythmias. Conclusions.Transplantation of mononuclear cord blood stem cells should not be considered as an additional arrhythmogenic risk factor in patients with refractory heart failure.http://csic.com.ua/images/pdf/2016/3-2016/heart-rhythm-safety-mononuclear-cord-blood-stem-cells-transplantation.pdfcord blood stem cellsarrhythmogenic effecttransplantationheart failure |
| spellingShingle | O.Yu. Usenko A.V. Yakushev O.V. Lisun M.V. Kostylev V.F. Onishchenko Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure Кардіохірургія та інтервенційна кардіологія cord blood stem cells arrhythmogenic effect transplantation heart failure |
| title | Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| title_full | Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| title_fullStr | Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| title_full_unstemmed | Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| title_short | Heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| title_sort | heart rhythm safety of the mononuclear cord blood stem cells transplantation in patients with refractory ischemic heart failure |
| topic | cord blood stem cells arrhythmogenic effect transplantation heart failure |
| url | http://csic.com.ua/images/pdf/2016/3-2016/heart-rhythm-safety-mononuclear-cord-blood-stem-cells-transplantation.pdf |
| work_keys_str_mv | AT oyuusenko heartrhythmsafetyofthemononuclearcordbloodstemcellstransplantationinpatientswithrefractoryischemicheartfailure AT avyakushev heartrhythmsafetyofthemononuclearcordbloodstemcellstransplantationinpatientswithrefractoryischemicheartfailure AT ovlisun heartrhythmsafetyofthemononuclearcordbloodstemcellstransplantationinpatientswithrefractoryischemicheartfailure AT mvkostylev heartrhythmsafetyofthemononuclearcordbloodstemcellstransplantationinpatientswithrefractoryischemicheartfailure AT vfonishchenko heartrhythmsafetyofthemononuclearcordbloodstemcellstransplantationinpatientswithrefractoryischemicheartfailure |