A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty pe...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2010-01-01
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| Series: | Molecular Systems Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/msb.2010.31 |
| _version_ | 1797281838017806336 |
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| author | Celine Lefebvre Presha Rajbhandari Mariano J Alvarez Pradeep Bandaru Wei Keat Lim Mai Sato Kai Wang Pavel Sumazin Manjunath Kustagi Brygida C Bisikirska Katia Basso Pedro Beltrao Nevan Krogan Jean Gautier Riccardo Dalla‐Favera Andrea Califano |
| author_facet | Celine Lefebvre Presha Rajbhandari Mariano J Alvarez Pradeep Bandaru Wei Keat Lim Mai Sato Kai Wang Pavel Sumazin Manjunath Kustagi Brygida C Bisikirska Katia Basso Pedro Beltrao Nevan Krogan Jean Gautier Riccardo Dalla‐Favera Andrea Califano |
| author_sort | Celine Lefebvre |
| collection | DOAJ |
| description | Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre‐replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues. |
| first_indexed | 2024-03-07T17:03:13Z |
| format | Article |
| id | doaj.art-ba8b8f4071d147eb81e0e478e6aff629 |
| institution | Directory Open Access Journal |
| issn | 1744-4292 |
| language | English |
| last_indexed | 2024-03-07T17:03:13Z |
| publishDate | 2010-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj.art-ba8b8f4071d147eb81e0e478e6aff6292024-03-03T03:11:51ZengSpringer NatureMolecular Systems Biology1744-42922010-01-0161n/an/a10.1038/msb.2010.31A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centersCeline Lefebvre0Presha Rajbhandari1Mariano J Alvarez2Pradeep Bandaru3Wei Keat Lim4Mai Sato5Kai Wang6Pavel Sumazin7Manjunath Kustagi8Brygida C Bisikirska9Katia Basso10Pedro Beltrao11Nevan Krogan12Jean Gautier13Riccardo Dalla‐Favera14Andrea Califano15Center for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USAInstitute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USAInstitute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University New York NY USADepartment of Cellular and Molecular Pharmacology, University of California at San Francisco San Francisco CA USADepartment of Cellular and Molecular Pharmacology, University of California at San Francisco San Francisco CA USAInstitute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University New York NY USAInstitute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University New York NY USACenter for Computational Biology and Bioinformatics, Columbia University New York NY USAAssembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module, where MYB and FOXM1 act as synergistic master regulators of proliferation in the germinal center (GC). Eighty percent of genes jointly regulated by these transcription factors are activated in the GC, including those encoding proteins in a complex regulating DNA pre‐replication, replication, and mitosis. These results indicate that the HBCI analysis can be used for the identification of determinants of major human cell phenotypes and provides a paradigm of general applicability to normal and pathologic tissues.https://doi.org/10.1038/msb.2010.31B cellgerminal centersinteractomemaster regulator |
| spellingShingle | Celine Lefebvre Presha Rajbhandari Mariano J Alvarez Pradeep Bandaru Wei Keat Lim Mai Sato Kai Wang Pavel Sumazin Manjunath Kustagi Brygida C Bisikirska Katia Basso Pedro Beltrao Nevan Krogan Jean Gautier Riccardo Dalla‐Favera Andrea Califano A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers Molecular Systems Biology B cell germinal centers interactome master regulator |
| title | A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers |
| title_full | A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers |
| title_fullStr | A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers |
| title_full_unstemmed | A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers |
| title_short | A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers |
| title_sort | human b cell interactome identifies myb and foxm1 as master regulators of proliferation in germinal centers |
| topic | B cell germinal centers interactome master regulator |
| url | https://doi.org/10.1038/msb.2010.31 |
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