Intra-ventral tegmental HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

Intra-ventral tegmental HIV-1 Tat1-86 attenuates nicotine-mediated locomotor sensitization and alters mesocorticolimbic ERK and CREB signaling in rats

Cigarette smoking prevalence in the HIV-positive individuals is profoundly higher than that in the HIV-negative individuals. We have demonstrated that HIV-1 transgenic rats exhibit attenuated nicotine-mediated locomotor activity, altered cAMP response element binding protein (CREB) and extracellular...

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Bibliographic Details
Main Authors: Jun eZhu, Narasimha M Midde, Adrian M Gomez, Wei-Lun eSun, Steven B Harrod
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Microbiology
Subjects:
Nicotine
Rats
ERK
locomotor activity
CREB
HIV-1 Tat
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00540/full

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