Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice
Stress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyg.2019.03028/full |
| _version_ | 1819017273768148992 |
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| author | Qiong Wang Yingjuan Liu Jianxu Zhang Weiwen Wang Weiwen Wang |
| author_facet | Qiong Wang Yingjuan Liu Jianxu Zhang Weiwen Wang Weiwen Wang |
| author_sort | Qiong Wang |
| collection | DOAJ |
| description | Stress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress inoculation on behaviors in novel predator odor exposure, open field test and forced swimming test (FST), and on the expression of CRF receptors in locus coeruleus (LC) and dorsal raphe nuclei (DRN). The results showed that predator odor stress inoculation increased the active coping of mice under the severe stress environment without changing the stress response to a new predator odor. Meanwhile, in LC, the CRFR1 expression was increased by predator odor stress inoculation. These results suggested that predator odor stress inoculation can be used as an effective training method to improve active response to later severe stress and the function of CRFR1 in LC might be a potential underlying biological mechanism. |
| first_indexed | 2024-12-21T03:00:55Z |
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| id | doaj.art-ba8df1c6fcd14f7bb26e7e6767982c8c |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-12-21T03:00:55Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-ba8df1c6fcd14f7bb26e7e6767982c8c2022-12-21T19:18:12ZengFrontiers Media S.A.Frontiers in Psychology1664-10782020-01-011010.3389/fpsyg.2019.03028502028Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in MiceQiong Wang0Yingjuan Liu1Jianxu Zhang2Weiwen Wang3Weiwen Wang4School of Education, Zhengzhou University, Zhengzhou, ChinaSchool of Life Sciences and Technology, Nanyang Normal University, Nanyang, ChinaState Key Laboratory of Integrated Management of Pest Insects and Rodents in Agriculture, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaCAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, ChinaDepartment of Psychology, University of Chinese Academy of Sciences, Beijing, ChinaStress inoculation has been proved to induce active coping behaviors to subsequent stress. However, the specific neural mechanisms underlying this effect remain unclear. In this study, a chronic and mild predator odor exposure model was established to investigate the effect of predator odor stress inoculation on behaviors in novel predator odor exposure, open field test and forced swimming test (FST), and on the expression of CRF receptors in locus coeruleus (LC) and dorsal raphe nuclei (DRN). The results showed that predator odor stress inoculation increased the active coping of mice under the severe stress environment without changing the stress response to a new predator odor. Meanwhile, in LC, the CRFR1 expression was increased by predator odor stress inoculation. These results suggested that predator odor stress inoculation can be used as an effective training method to improve active response to later severe stress and the function of CRFR1 in LC might be a potential underlying biological mechanism.https://www.frontiersin.org/article/10.3389/fpsyg.2019.03028/fullstress inoculationpredator odor exposureactive copingcorticotropin-releasing factor receptorslocus coeruleusdorsal raphe nuclei |
| spellingShingle | Qiong Wang Yingjuan Liu Jianxu Zhang Weiwen Wang Weiwen Wang Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice Frontiers in Psychology stress inoculation predator odor exposure active coping corticotropin-releasing factor receptors locus coeruleus dorsal raphe nuclei |
| title | Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice |
| title_full | Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice |
| title_fullStr | Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice |
| title_full_unstemmed | Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice |
| title_short | Corticotropin-Releasing Factor Receptors in the Locus Coeruleus Modulate the Enhancement of Active Coping Behaviors Induced by Chronic Predator Odor Inoculation in Mice |
| title_sort | corticotropin releasing factor receptors in the locus coeruleus modulate the enhancement of active coping behaviors induced by chronic predator odor inoculation in mice |
| topic | stress inoculation predator odor exposure active coping corticotropin-releasing factor receptors locus coeruleus dorsal raphe nuclei |
| url | https://www.frontiersin.org/article/10.3389/fpsyg.2019.03028/full |
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