Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation

Imprinted and ancient gene: a potential mediator of cancer cell survival during tryptophan deprivation

Abstract Background Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer cells in the same microenvironment appear not to be affected. Mechanism...

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Bibliographic Details
Main Authors: Petr Tomek, Shanti K. Gore, Chloe L. Potts, Cristin G. Print, Michael A. Black, Ariane Hallermayr, Michael Kilian, Evelyn Sattlegger, Lai-Ming Ching
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Cell Communication and Signaling
Subjects:
IMPACT
IDO1
Immune suppression
Cancer cell survival
Online Access:http://link.springer.com/article/10.1186/s12964-018-0301-7

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