THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Luchevaya Diagnostika, LLC
2017-05-01
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| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/210 |
| Summary: | The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to that in older children and adults. Gadobutrol given at a standard dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children of any age and by adults. There is evidence that the use of gadobutrol may be extrapolated to infants younger than 2 years of age, including full-term neonates, for the effective diagnosis of blood-brain barrier disorders, pathological changes in the cardiovascular system, and focal diseases of the internal organs of the whole body. |
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| ISSN: | 0042-4676 2619-0478 |