THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS
The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to t...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Luchevaya Diagnostika, LLC
2017-05-01
|
| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/210 |
| _version_ | 1797341716880031744 |
|---|---|
| author | A. A. Alikhanov N. L. Shimanovskiy |
| author_facet | A. A. Alikhanov N. L. Shimanovskiy |
| author_sort | A. A. Alikhanov |
| collection | DOAJ |
| description | The paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to that in older children and adults. Gadobutrol given at a standard dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children of any age and by adults. There is evidence that the use of gadobutrol may be extrapolated to infants younger than 2 years of age, including full-term neonates, for the effective diagnosis of blood-brain barrier disorders, pathological changes in the cardiovascular system, and focal diseases of the internal organs of the whole body. |
| first_indexed | 2024-03-08T10:21:56Z |
| format | Article |
| id | doaj.art-ba91609b1f8946109684b9a4ba2f4530 |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:21:56Z |
| publishDate | 2017-05-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-ba91609b1f8946109684b9a4ba2f45302024-01-27T18:38:34ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782017-05-019829710210.20862/0042-4676-2017-98-2-97-102171THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTSA. A. Alikhanov0N. L. Shimanovskiy1Russian State Children Hospital, Ministry of Health of the RFPirogov Russian National Research Medical University, Ministry of Health of the RFThe paper provides information on the safety, diagnostic efficiency, and bioequivalence of using gadobutrol in neonates and babies compared to older children and adult patients. In infants aged less than 2 years, including full-term newborns, the pharmacokinetic profile of gadobutrol is similar to that in older children and adults. Gadobutrol given at a standard dose of 0.1 mmol/kg body weight has a favorable safety profile and is well tolerated by children of any age and by adults. There is evidence that the use of gadobutrol may be extrapolated to infants younger than 2 years of age, including full-term neonates, for the effective diagnosis of blood-brain barrier disorders, pathological changes in the cardiovascular system, and focal diseases of the internal organs of the whole body.https://www.russianradiology.ru/jour/article/view/210reviewmagnetic resonance imagingcontrast-enhancedgadobutrolneonatesbabiespharmacokineticsmacrocyclic compaund |
| spellingShingle | A. A. Alikhanov N. L. Shimanovskiy THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS Вестник рентгенологии и радиологии review magnetic resonance imaging contrast-enhanced gadobutrol neonates babies pharmacokinetics macrocyclic compaund |
| title | THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS |
| title_full | THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS |
| title_fullStr | THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS |
| title_full_unstemmed | THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS |
| title_short | THE DIAGNOSTIC EFFICACY, SAFETY AND BIOEQUIVALENCE OF GADOBUTROL USED IN INFANTS AGED LESS THAN 2 YEARS COMPARED WITH OLDER CHILDREN AND ADULTS |
| title_sort | diagnostic efficacy safety and bioequivalence of gadobutrol used in infants aged less than 2 years compared with older children and adults |
| topic | review magnetic resonance imaging contrast-enhanced gadobutrol neonates babies pharmacokinetics macrocyclic compaund |
| url | https://www.russianradiology.ru/jour/article/view/210 |
| work_keys_str_mv | AT aaalikhanov thediagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults AT nlshimanovskiy thediagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults AT aaalikhanov diagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults AT nlshimanovskiy diagnosticefficacysafetyandbioequivalenceofgadobutrolusedininfantsagedlessthan2yearscomparedwitholderchildrenandadults |