Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma
Primary liver cancer is the sixth most common cancer and the third leading cause of cancer mortality worldwide, hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%–85% of cases. The occurrence and progression of HCC involve multiple events. Pyroptosis is a gasd...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022023234 |
| _version_ | 1797991710579490816 |
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| author | Yandong Miao Yonggang Chen Denghai Mi |
| author_facet | Yandong Miao Yonggang Chen Denghai Mi |
| author_sort | Yandong Miao |
| collection | DOAJ |
| description | Primary liver cancer is the sixth most common cancer and the third leading cause of cancer mortality worldwide, hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%–85% of cases. The occurrence and progression of HCC involve multiple events. Pyroptosis is a gasdermins mediated programmed cell death and is intricately associated with cancerogenesis, including HCC. This review mainly concerns the recent research advances of the gasdermin family members in HCC. The biological roles and specific expression patterns of the family members are discussed, especially those that are involved in the regulatory pathways in the occurrence and progression of HCC. We provide the latest progress into the distinct molecular mechanisms of gasdermin family members involved in the occurrence and development of HCC. |
| first_indexed | 2024-04-11T08:56:43Z |
| format | Article |
| id | doaj.art-ba91ad09356e4079a7e756430e116aad |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T08:56:43Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ba91ad09356e4079a7e756430e116aad2022-12-22T04:33:17ZengElsevierHeliyon2405-84402022-10-01810e11035Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinomaYandong Miao0Yonggang Chen1Denghai Mi2The Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264000, Shandong Province, China; Corresponding author.Shenzhen Hospital of Southern Medical University, Shenzhen 518100, Guangdong Province, ChinaGansu Academy of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, ChinaPrimary liver cancer is the sixth most common cancer and the third leading cause of cancer mortality worldwide, hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%–85% of cases. The occurrence and progression of HCC involve multiple events. Pyroptosis is a gasdermins mediated programmed cell death and is intricately associated with cancerogenesis, including HCC. This review mainly concerns the recent research advances of the gasdermin family members in HCC. The biological roles and specific expression patterns of the family members are discussed, especially those that are involved in the regulatory pathways in the occurrence and progression of HCC. We provide the latest progress into the distinct molecular mechanisms of gasdermin family members involved in the occurrence and development of HCC.http://www.sciencedirect.com/science/article/pii/S2405844022023234Hepatocellular carcinomaPyroptosisGasderminLiver cancer |
| spellingShingle | Yandong Miao Yonggang Chen Denghai Mi Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma Heliyon Hepatocellular carcinoma Pyroptosis Gasdermin Liver cancer |
| title | Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| title_full | Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| title_fullStr | Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| title_full_unstemmed | Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| title_short | Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| title_sort | role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Pyroptosis Gasdermin Liver cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022023234 |
| work_keys_str_mv | AT yandongmiao roleofgasderminfamilyproteinsintheoccurrenceandprogressionofhepatocellularcarcinoma AT yonggangchen roleofgasderminfamilyproteinsintheoccurrenceandprogressionofhepatocellularcarcinoma AT denghaimi roleofgasderminfamilyproteinsintheoccurrenceandprogressionofhepatocellularcarcinoma |