Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

Mutations in WNK kinases cause the human hypertensive disease pseudohypoaldosteronism type II (PHAII), but the regulatory mechanisms of the WNK kinases are not well understood. Mutations in kelch-like 3 (KLHL3) and Cullin3 were also recently identified as causing PHAII. Therefore, new insights into...

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Bibliographic Details
Main Authors: Mai Wakabayashi, Takayasu Mori, Kiyoshi Isobe, Eisei Sohara, Koichiro Susa, Yuya Araki, Motoko Chiga, Eriko Kikuchi, Naohiro Nomura, Yutaro Mori, Hiroshi Matsuo, Tomohiro Murata, Shinsuke Nomura, Takako Asano, Hiroyuki Kawaguchi, Shigeaki Nonoyama, Tatemitsu Rai, Sei Sasaki, Shinichi Uchida
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713001009

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